•  4
    Ethics of non-therapeutic research on imminently dying patients in the intensive care unit
    with Nicholas Murphy, Derek Debicki, Geoffrey Laforge, Loretta Norton, Teneille Gofton, and Marat Slessarev
    Journal of Medical Ethics 49 (5): 311-318. 2023.
    Non-therapeutic research with imminently dying patients in intensive care presents complex ethical issues. The vulnerabilities of the imminently dying, together with societal disquiet around death and dying, contribute to an intuition that such research is beyond the legitimate scope of scientific inquiry. Yet excluding imminently dying patients from research hinders the advancement of medical science to the detriment of future patients. Building on existing ethical guidelines for research, we p…Read more
  •  2
    Trial by Error (review)
    Hastings Center Report 31 (1): 47. 2001.
  • Ethical Issues Posed by Cluster Randomized Trials in Health Research
    with Jeremy M. Grimshaw, Monica Taljaard, Ariella Binik, Robert Boruch, Jamie C. Brehaut, Allan Donner, Martin P. Eccles, Antonio Gallo, Andrew D. McRae, and Ray Saginur
    Trials 1 (12): 100. 2011.
  • The COVID-19 pandemic touched off an unprecedented search for vaccines and treatments. Without question, the development of vaccines to prevent COVID-19 was an enormous scientific accomplishment. Further, the RECOVERY and Solidarity trials identified effective treatments for COVID-19. But all was not success. The urgent need for COVID-19 prevention and treatment fueled an embrace of risks—to research participants and to the reliability of the science itself—as allegedly necessary costs to speed …Read more
  • Stepped-wedge trials should be classified as research for the purpose of ethical review
    with Karla Hemming, Monica Taljaard, Tom Marshall, and Cory E. Goldstein
    Clinical Trials 16 (6): 580-588. 2019.
  • Does clinical equipoise apply to cluster randomized trials in health research?
    with Ariella Binik, Andrew McRae, Jeremy Grimshaw, Monica Taljaard, Robert Boruch, Jamie Brehaut, Allan Donner, Martin Eccles, Antonio Gallo, Raphael Saginur, and Merrick Zwarenstein
    Trials 12. 2011.
  • Who is the research subject in cluster randomized trials in health research?
    with Andrew D. McRae, Ariella Binik, Jeremy M. Grimshaw, Monica Taljaard, Robert Boruch, Jamie C. Brehaut, Allan Donner, Martin P. Eccles, Antonio Gallo, Ray Saginur, and Merrick Zwarenstein
    Trials 1 (12): 118. 2011.
  • Accommodating quality and service improvement research within existing ethical principles
    with Cory E. Goldstein, Jamie Brehaut, Marion Campbell, Dean A. Fergusson, Jeremy M. Grimshaw, Karla Hemming, Austin R. Horn, and Monica Taljaard
    Trials 19 (1): 334. 2018.
    Quality and service improvement (QSI) research employs a broad range of methods to enhance the efficiency of healthcare delivery. QSI research differs from traditional healthcare research and poses unique ethical questions. Since QSI research aims to generate knowledge to enhance quality improvement efforts, should it be considered research for regulatory purposes? Is review by a research ethics committee required? Should healthcare providers be considered research participants? If participation…Read more
  • Not for Distribution
    Journal of Law, Medicine and Ethics 28 344-361. 2000.
  • When is informed consent required in cluster randomized trials in health research?
    with Andrew D. McRae, Ariella Binik, Angela White, Jeremy M. Grimshaw, Robert Boruch, Jamie C. Brehaut, Allan Donner, Martin P. Eccles, Raphael Saginur, Merrick Zwarenstein, and Monica Taljaard
    Trials 1 (12): 202. 2011.