•  118
    Structuring the Review of Human Genetics Protocols
    with Kathleen Cranley Glass, Denis Cournoyer, Trudo Lemmens, Roberta M. Palmour, Stanley H. Shapiro, and Benjamin Freedman
    IRB: Ethics & Human Research 21. 1999.
  •  56
    Assay Sensitivity and the Epistemic Contexts of Clinical Trials
    Perspectives in Biology and Medicine 56 (1): 1-17. 2013.
    In February 2010, the World Medical Association hosted an international symposium on the ethics of placebo controls in clinical trials (WMA 2010). Despite years of debate, ethicists, clinical trialists, and policy makers remain divided over the ethical acceptability of using placebos in research when a proven, effective treatment is available. The protracted nature of this problem is due, at least in part, to a perceived conflict between the opposing demands placed on clinical research by scienc…Read more
  •  53
    Ethics, economics and the regulation and adoption of new medical devices: case studies in pelvic floor surgery
    with Sue Ross, Amiram Gafni, Ariel Ducey, Carmen Thompson, and Rene Lafreniere
    BMC Medical Ethics 11 (1): 14-. 2010.
    Background: Concern has been growing in the academic literature and popular media about the licensing, introduction and adoption of surgical devices before full effectiveness and safety evidence is available to inform clinical practice. Our research will seek empirical survey evidence about the roles, responsibilities, and information and policy needs of the key stakeholders in the introduction into clinical practice of new surgical devices for pelvic floor surgery, in terms of the underlying et…Read more
  •  28
    Integrating Bioethics and Health Law Into the Canadian Institutes of Health Research
    with Susan Sherwin, Françoise Baylis, Alan Bernstein, Timothy Caulfield, Bernard Dickens, Jocelyn Downie, Bartha Knoppers, Thérèse Leroux, Neil MacDonald, Michael McDonald, and Janet Storch
  •  22
    Bioethics for Clinicians: 16. Dealing with Demands for Inappropriate Treatment
    with Peter A. Singer, Bernard M. Dickens, and Stephen Workman
    Demands by Patients or their Families for treatment thought to be inappropriate by health care providers constitute an important set of moral problems in clinical practice. A variety of approaches to such cases have been described in the literature, including medical futility, standard of care and negotiation. Medical futility fails because it confounds morally distinct cases: demand for an ineffective treatment and demand for an effective treatment that supports a controversial end (e.g., perma…Read more
  •  29
    Hospital Policy on Appropriate Use of Life-sustaining Treatment
    with Peter A. Singer, Geoff Barker, Kerry W. Bowman, Christine Harrison, Philip Kernerman, Judy Kopelow, Neil Lazar, and Stephen Workman
    OBJECTIVE: To describe the issues faced, and how they were addressed, by the University of Toronto Critical Care Medicine Program/Joint Centre for Bioethics Task Force on Appropriate Use of Life-Sustaining Treatment. The clinical problem addressed by the Task Force was dealing with requests by patients or substitute decision makers for life-sustaining treatment that their healthcare providers believe is inappropriate. DESIGN: Case study. SETTING: The University of Toronto Joint Centre for Bioeth…Read more
  •  10
    Placebo-controlled Studies in Schizophrenia: Ethical and Scientific Perspectives. Panel Discussion
    with T. M. Lemmens, P. S. Appelbaum, W. Carpenter, C. McCarthy, C. Peterson, and D. Streiner
  •  91
    Unethical Author Attribution
    with Anonymous M. D./PhD Student and Akira Akabayashi
    Cambridge Quarterly of Healthcare Ethics 12 (1): 124-130. 2003.
    I am an M.D/Ph.D. student and work as a research assistant for the director of a division of the school of medicine who is an M.D. He assigned me to research a certain topic and gave me no guidelines or guidance as to how to do it. Nevertheless, I did the research and wrote it up. My supervisor liked the report and said that he thought it was so good that “I would like to offer you the opportunity to publish it and list you as the primary author.” Some bells went off when he so grandly offered t…Read more
  •  12
    This presentation addresses these questions: • “Upon what ethical grounds may the physician offer RCT enrollment to a patient?” • Which is the preferred moral basis of the RCT?
  •  8
    Placebo Controls Are Not Good Science
    IRB: Ethics & Human Research 18 (5): 8. 1996.
  •  9
    Informing Patients of Uncertainty in Clinical Trials
    with S. D. Halpern and J. H. Karlawish