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12Deep Brain Stimulation and Changes in “Personality”: A Catch-All with Merits and PitfallsAmerican Journal of Bioethics Neuroscience 14 (3): 320-322. 2023.The 30th anniversary of the first DBS surgery of the subthalamic nucleus (STN) for Parkinson’s disease was celebrated in Grenoble this June. Since this initial surgery, the application of DBS has e...
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14Alienation and Authenticity in Parkinson's Disease and Its TreatmentAmerican Journal of Bioethics Neuroscience 5 (4): 54-56. 2014.Why are some patients with Parkinson's disease unhappy about the outcome of deep brain stimulation (DBS)? Meccaci and Haselager (2014) attempt to answer this question by analyzing the seminal case...
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54I Miss Being Me: Phenomenological Effects of Deep Brain StimulationAmerican Journal of Bioethics Neuroscience 8 (2): 96-109. 2017.The phenomenological effects of deep brain stimulation (DBS) on the self of the patient remains poorly understood and under described in the literature, despite growing evidence that a significant number of patients experience postoperative neuropsychiatric changes. To address this lack of phenomenological evidence, we conducted in-depth, semistructured interviews with 17 patients with Parkinson's disease who had undergone DBS. Exploring the subjective character specific to patients' experience …Read more
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19Throwing the Ethics Book at Professional Organizations in the Neurological SciencesAmerican Journal of Bioethics Neuroscience 8 (4). 2017.
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24Surveillance Medicine in the DigitalEra: Lessons From Addiction TreatmentAmerican Journal of Bioethics 18 (9): 58-60. 2018.
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28Ethical, Social and Clinical Challenges in using Deep Brain Stimulation to Treat Addiction and Other Impulsive and Compulsive DisordersJahrbuch für Wissenschaft Und Ethik 19 (1): 163-188. 2015.Name der Zeitschrift: Jahrbuch für Wissenschaft und Ethik Jahrgang: 19 Heft: 1 Seiten: 163-188
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11A principle‐based framework for disclosing a psychosis risk diagnosisBioethics 37 (2): 171-182. 2022.In recent decades, researchers have attempted to prospectively identify individuals at high risk of developing psychosis in the hope of delaying or preventing psychosis onset. These psychosis risk individuals are identified as being in an ‘At-Risk Mental State’ (ARMS) through a standardised psychometric interview. However, disclosure of ARMS status has attracted criticism due to concerns about the risk–benefit ratio of disclosure to patients. Only approximately one quarter of ARMS patients devel…Read more
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17The Coercive Potential of Digital Mental HealthAmerican Journal of Bioethics 21 (7): 28-30. 2021.Digital mental health can be understood as the in situ quantification of an individual’s data from personal devices to measure human behavior in both health and disease (Huckvale, Venkatesh and Chr...
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32Drug Legalization is Not a Masterstroke for Addressing Racial InequalityAmerican Journal of Bioethics 21 (4): 44-46. 2021.Brian Earp and colleagues argue that the major harms associated with the use of illicit drugs largely arise from, or are at least exacerbated by, the fact that their use attracts criminal pe...
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14Informed Consent and Voluntariness: Balancing Ethical Demands During Trial RecruitmentAmerican Journal of Bioethics Neuroscience 12 (1): 83-85. 2021.
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14Changes in Personality Associated with Deep Brain Stimulation: a Qualitative Evaluation of Clinician PerspectivesNeuroethics 14 (1): 109-124. 2019.Gilbert et al. argue that the neuroethics literature discussing the putative effects of Deep Brain Stimulation on personality largely ignores the scientific evidence and presents distorted claims that personality change is induced by the DBS stimulation. This study contributes to the first-hand primary research on the topic exploring DBS clinicians’ views on post-DBS personality change among their patients and its underlying cause. Semi-structured interviews were conducted with sixteen clinician…Read more
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11Changes in Personality Associated with Deep Brain Stimulation: a Qualitative Evaluation of Clinician PerspectivesNeuroethics 14 (1): 109-124. 2019.Gilbert et al. argue that the neuroethics literature discussing the putative effects of Deep Brain Stimulation on personality largely ignores the scientific evidence and presents distorted claims that personality change is induced by the DBS stimulation. This study contributes to the first-hand primary research on the topic exploring DBS clinicians’ views on post-DBS personality change among their patients and its underlying cause. Semi-structured interviews were conducted with sixteen clinician…Read more
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9Beyond Flourishing: Intersecting Uses and Interests in the Neurotechnology MarketplaceAmerican Journal of Bioethics Neuroscience 10 (4): 178-180. 2019.
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19Changes in Personality Associated with Deep Brain Stimulation: a Qualitative Evaluation of Clinician PerspectivesNeuroethics 14 (1): 109-124. 2019.Gilbert et al. argue that the neuroethics literature discussing the putative effects of Deep Brain Stimulation on personality largely ignores the scientific evidence and presents distorted claims that personality change is induced by the DBS stimulation. This study contributes to the first-hand primary research on the topic exploring DBS clinicians’ views on post-DBS personality change among their patients and its underlying cause. Semi-structured interviews were conducted with sixteen clinician…Read more
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25Advancing Medicine Ethically: Important Considerations for Innovative PracticeAmerican Journal of Bioethics 19 (6): 38-40. 2019.Earl (2019) argues that the current uniform restriction of innovative practice limits clinicians’ ability to provide optimal treatment and stunts progress in medicine. We agree that it is important...
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34Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease can lead to the development of neuropsychiatric symptoms. These can include harmful changes in mood and behaviour that alienate family members and raise ethical questions about personal responsibility for actions committed under stimulation-dependent mental states. Qualitative interviews were conducted with twenty participants following subthalamic DBS at a movement disorders centre, in order to explore th…Read more
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12Of Meatballs And Invasive Neurotechnological Trials: Additional Considerations for Complex Clinical DecisionsAmerican Journal of Bioethics Neuroscience 9 (2): 100-104. 2018.Using this case, Lavazza and Reichlin (2018) explored the ethical dilemmas associated with decision making in people with Alzheimer’s disease (AD), specifically when their new preferences conflict...
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21Curing Psychopathy: Just Activate the Amygdala?American Journal of Bioethics Neuroscience 7 (3): 164-166. 2016.
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20Addiction May Not Be a Compulsive Brain Disease, But It Is More Than Purposeful Medication of Untreated Psychiatric DisordersAmerican Journal of Bioethics Neuroscience 3 (2): 54-55. 2012.
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21An Ethical Reevaluation: Where Are the Voices of Those With Anorexia Nervosa and Their Families?American Journal of Bioethics Neuroscience 6 (4): 73-74. 2015.
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17Managing Suicide Risk in Experimental Treatments of Treatment-Resistant DepressionAmerican Journal of Bioethics Neuroscience 4 (1): 38-39. 2013.
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9Justice and Equity in Trials of Deep Brain Stimulation for the Treatment of Addiction and OvereatingAmerican Journal of Bioethics Neuroscience 4 (2): 54-56. 2013.
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14Beyond the Right to Injectable HeroinAmerican Journal of Bioethics Neuroscience 1 (1): 48-49. 2010.
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11Deep Brain Stimulation in Parkinsonian Patients—Implications for Trialing DBS in Intractable Psychiatric DisordersAmerican Journal of Bioethics Neuroscience 2 (1): 14-15. 2011.
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29Ethical Guidelines for Genetic Research on Alcohol Addiction and Its ApplicationsKennedy Institute of Ethics Journal 28 (1): 1-22. 2018.The misuse of alcohol inflicts a major toll on individual users, their families, and the wider society. This includes disruptions of family life, violence, absenteeism and problems in the workplace, child neglect and abuse, and excess morbidity and mortality. The World Health Organization estimates that alcohol ranks eighth among global risk factors for death and is the third leading global risk factor for disease and disability. In the United States, alcohol dependence affects four to five perc…Read more
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Empirical research with Markov regime-switching models often requires the researcher not only to estimate the model but also to test for the presence of more than one regime. Despite the need for both estimation and testing, methods of estimation are better understood than are methods of testing. We bridge this gap by explaining, in detail, how to apply the newest results in the theory of regime testing, developed by Cho and White [Cho, J. S., and H. White 2007. “Testing for Regime Switching.” E…Read more
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22Standing at the Precipice: A Cautionary Note About Incremental GoodsAmerican Journal of Bioethics Neuroscience 1 (3): 46-48. 2010.
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114Ethical Issues Raised by Proposals to Treat Addiction Using Deep Brain StimulationNeuroethics 4 (2): 129-142. 2010.Deep brain stimulation (DBS) has been proposed as a potential treatment of drug addiction on the basis of its effects on drug self-administration in animals and on addictive behaviours in some humans treated with DBS for other psychiatric or neurological conditions. DBS is seen as a more reversible intervention than ablative neurosurgery but it is nonetheless a treatment that carries significant risks. A review of preclinical and clinical evidence for the use of DBS to treat addiction suggests t…Read more
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49Disease or Developmental Disorder: Competing Perspectives on the Neuroscience of AddictionNeuroethics 10 (1): 103-110. 2017.Lewis’ neurodevelopmental model provides a plausible alternative to the brain disease model of addiction that is a dominant perspective in the USA. We disagree with Lewis’ claim that the BDMA is unchallenged within the addiction field but we agree that it provides unduly pessimistic prospects of recovery. We question the strength of evidence for the BDMA provided by animal models and human neuroimaging studies. We endorse Lewis’ framing of addiction as a developmental process underpinned by reve…Read more
Clayton, Victoria, Australia