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    Stimulation of innate immune cells by light-activated TLR7/8 agonists
    with K. A. Ryu, L. Stutts, Tom J. K., and R. J. Mancini
    The innate immune response is controlled, in part, by the synergistic interaction of multiple Toll-like receptors. This multi-receptor cooperation is responsible for the potent activity of many vaccines, but few tools have been developed to understand the spatio-temporal elements of TLR synergies. In this Communication, we present photo-controlled agonists of TLR7/8. By strategically protecting the active agonist moiety based on an agonist-bound crystal structure, TLR activity is suppressed and …Read more