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3The innate immune response is controlled, in part, by the synergistic interaction of multiple Toll-like receptors. This multi-receptor cooperation is responsible for the potent activity of many vaccines, but few tools have been developed to understand the spatio-temporal elements of TLR synergies. In this Communication, we present photo-controlled agonists of TLR7/8. By strategically protecting the active agonist moiety based on an agonist-bound crystal structure, TLR activity is suppressed and …Read more
St. Louis, Missouri, United States of America
Areas of Interest
Metaphysics |
Applied Ethics |
Social and Political Philosophy |