Amit Tripathi

The public health crisis is started with emergence of new coronavirus on 11 February 2020 which triggered as coronavirus disease-2019 (COVID-19) pandemics. The causative agent in COVID-19 is made up of positively wrapped single-stranded RNA viruses ~ 30 kb in size. The epidemiology, clinical features, pathophysiology, and mode of transmission have been documented well in many studies, with additional clinical trials are running for several antiviral agents. The spreading potential of COVID-19 is faster than its two previous families, the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV). Apart from clinical manifestation, comorbid status is playing key role for prevalence of COVID-19 infection and mortalities. The comorbid effects associated with COVID-19 are diabetes, cardiovascular, digestive, hepatitis-B, cerebrovascular, hypertension, liver injury, coronary heart disease, cancer, rheumatoid arthritis, and neurological impairment. Antimalarial drugs (chloroquine and hydroxychloroquine), remdesivir, Tocilizumab, clopinavir/ritonavir, convalescent plasma therapy, spike protein-angiotensin-converting enzyme 2 (ACE2) inhibitors, human monoclonal antibodies, mRNA-1273, mesenchymal stem cells, Indian and Chinese traditional medicine, small molecules antioxidant, natural products and dietary supplements, high doses of vitamin-E, -C, -D, minerals, flavonoids,and IFN-beta are therapeutic intervention running to develop treatment against COVID-19. Although clinical usage of these therapeutic agents against COVID-19 is well documented, cytokine storms, absence of appropriate animal model have limited its therapeutic use. This review explores the clinical information currently available on COVID-19 on the mechanisms of infection, prevention, management, comorbid status, and current drug treatment options.

In the collectivist culture of India, family occupies a central place in organizing social and personal lives of the people. However, the forces of industrialization and urbanization are changing the life style and leading to reprioritization of values. Against this backdrop this study examined the pattern of actual and desired family values in the context of ecology, family type and generation. The sample ( n = 90) was drawn from urban, semi-urban and rural areas in central India representing parent–child pairs belonging to joint and nuclear families. Using an indigenously developed measure of family values the study revealed that ecological setting and generation significantly influenced the family value of positive interaction. The type of family emerged as a significant factor for three major values, that is, social order, manners and helping. The interaction of ecology, family type and generation were significant for the values of social order and helping. In general, the type of family and ecological setting yielded major influence in shaping values. The implications of the findings for parenting are discussed.