• Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
    with N. Johnson, F. Dudbridge, N. Orr, L. Gibson, M. E. Jones, M. J. Schoemaker, E. J. Folkerd, B. P. Haynes, J. L. Hopper, M. C. Southey, G. S. Dite, C. Apicella, M. K. Schmidt, A. Broeks, L. J. Van'T. Veer, F. Atsma, K. Muir, A. Lophatananon, P. A. Fasching, M. W. Beckmann, A. B. Ekici, S. P. Renner, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, B. Burwinkel, F. Marme, C. Sohn, P. Guénel, T. Truong, E. Cordina, F. Menegaux, S. E. Bojesen, B. G. Nordestgaard, H. Flyger, R. Milne, M. P. Zamora, J. I. Arias Perez, J. Benitez, L. Bernstein, H. Anton-Culver, A. Ziogas, C. Clarke Dur, H. Brenner, H. Müller, V. Arndt, A. K. Dieffenbach, A. Meindl, J. Heil, C. R. Bartram, R. K. Schmutzler, H. Brauch, C. Justenhoven, Y. D. Ko, H. Nevanlinna, T. A. Muranen, K. Aittomäki, C. Blomqvist, K. Matsuo, T. Dörk, N. V. Bogdanova, N. N. Antonenkova, A. Lindblom, A. Mannermaa, V. Kataja, V. M. Kosma, J. M. Hartikainen, G. Chenevix-Trench, J. Beesley, A. H. Wu, D. Van den Berg, C. C. Tseng, and D. Lambrechts
    INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism, which maps to the CYP3A locus, was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.METHODS: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Geno…Read more
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    Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: A case-control study
    with N. Johnson, F. Dudbridge, N. Orr, L. Gibson, M. E. Jones, M. J. Schoemaker, E. J. Folkerd, B. P. Haynes, J. L. Hopper, M. C. Southey, G. S. Dite, C. Apicella, M. K. Schmidt, A. Broeks, L. J. Van'T. Veer, F. Atsma, K. Muir, A. Lophatananon, P. A. Fasching, M. W. Beckmann, A. B. Ekici, S. P. Renner, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, B. Burwinkel, F. Marme, C. Sohn, P. Guénel, T. Truong, E. Cordina, F. Menegaux, S. E. Bojesen, B. G. Nordestgaard, H. Flyger, R. Milne, M. P. Zamora, J. I. A. Perez, J. Benitez, L. Bernstein, H. Anton-Culver, A. Ziogas, C. C. Dur, H. Brenner, H. Müller, V. Arndt, A. K. Dieffenbach, A. Meindl, J. Heil, C. R. Bartram, R. K. Schmutzler, H. Brauch, C. Justenhoven, Y. D. Ko, H. Nevanlinna, T. A. Muranen, K. Aittomäki, C. Blomqvist, K. Matsuo, T. Dörk, N. V. Bogdanova, N. N. Antonenkova, A. Lindblom, A. Mannermaa, V. Kataja, V. M. Kosma, J. M. Hartikainen, G. Chenevix-Trench, J. Beesley, A. H. Wu, D. Van den Berg, C. C. Tseng, and D. Lambrechts
    © 2014 Johnson et al.Introduction: We have previously shown that a tag single nucleotide polymorphism, which maps to the CYP3A locus, was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Associ…Read more