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Tramadol is an opioid agonist that may be used to treat moderate to moderately severe chronic pain in adults.

Extended-release forms of tramadol may be used in adults who require around-the-clock treatment of their pain for an extended period. Brands of tramadol include ConZip, Qdolo, Ultram, and Ultram ER. Generic tramadol is available.

Tramadol was first FDA-approved on March 3, 1995. Originally it was classified as a non-controlled substance but it was reclassified in 2014 to Schedule IV of the Controlled Substances Act with restrictions on its prescribing.

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