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    In a Flemish kindred, an Ala692 → Gly amino acid substitution in the amyloid β-protein precursor causes a form of early-onset Alzheimer's disease which displays prominent amyloid angiopathy and unusually large senile plaque cores. The mechanistic basis of this Flemish form of AD is unknown. Previous in vitro studies of amyloid β-protein production in HEK-293 cells transfected with cDNA encoding Flemish AβPP have shown that full-length [Aβ]and truncated [Aβ and Aβ] forms of Aβ are produced. In an…Read more