Kanazawa University
Graduate School of Natural Science and Technology
PhD, 2008
Los Angeles, California, United States
  •  953
    Quantum information theoretic approach to the mind–brain problem
    Progress in Biophysics and Molecular Biology 158 16-32. 2020.
    The brain is composed of electrically excitable neuronal networks regulated by the activity of voltage-gated ion channels. Further portraying the molecular composition of the brain, however, will not reveal anything remotely reminiscent of a feeling, a sensation or a conscious experience. In classical physics, addressing the mind–brain problem is a formidable task because no physical mechanism is able to explain how the brain generates the unobservable, inner psychological world of conscious exp…Read more
  •  234
    Evolution of Consciousness
    Life 14 (1): 48. 2024.
    The natural evolution of consciousness in different animal species mandates that conscious experiences are causally potent in order to confer any advantage in the struggle for survival. Any endeavor to construct a physical theory of consciousness based on emergence within the framework of classical physics, however, leads to causally impotent conscious experiences in direct contradiction to evolutionary theory since epiphenomenal consciousness cannot evolve through natural selection. Here, we re…Read more
  •  165
    Causal potency of consciousness in the physical world
    International Journal of Modern Physics B 2450256. forthcoming.
    The evolution of the human mind through natural selection mandates that our conscious experiences are causally potent in order to leave a tangible impact upon the surrounding physical world. Any attempt to construct a functional theory of the conscious mind within the framework of classical physics, however, inevitably leads to causally impotent conscious experiences in direct contradiction to evolution theory. Here, we derive several rigorous theorems that identify the origin of the latter impa…Read more
  •  168
    This study is intended to provide in-depth insights into how design thinking and creativity issues are understood and possibly evolve in the course of design discussions in a company context. For that purpose, we use the seminar transcripts of the Design Thinking Research Symposium 12 (DTRS12) dataset “Tech-centred Design Thinking: Perspectives from a Rising Asia,” which are primarily concerned with how Korean companies implement design thinking and what role designers currently play. We employe…Read more
  •  16
    Entanglement measures for two-particle quantum histories
    with Eliahu Cohen
    Physical Review A 106 (6): 062437. 2022.
    Quantum entanglement is a key resource, which grants quantum systems the ability to accomplish tasks that are classically impossible. Here, we apply Feynman's sum-over-histories formalism to interacting bipartite quantum systems and introduce entanglement measures for bipartite quantum histories. Based on the Schmidt decomposition of the matrix comprised of the Feynman propagator complex coefficients, we prove that bipartite quantum histories are entangled if and only if the Schmidt rank of this…Read more
  •  132
    Quantum tunneling of three-spine solitons through excentric barriers
    with James F. Glazebrook
    Physics Letters A 448 128319. 2022.
    Macromolecular protein complexes catalyze essential physiological processes that sustain life. Various interactions between protein subunits could increase the effective mass of certain peptide groups, thereby compartmentalizing protein α-helices. Here, we study the differential effects of applied massive barriers upon the soliton-assisted energy transport within proteins. We demonstrate that excentric barriers, localized onto a single spine in the protein α-helix, reflect or trap three-spine so…Read more
  •  190
    Sensitivity of entanglement measures in bipartite pure quantum states
    with Stanley P. Gudder
    Modern Physics Letters B 36 (22): 2250101. 2022.
    Entanglement measures quantify the amount of quantum entanglement that is contained in quantum states. Typically, different entanglement measures do not have to be partially ordered. The presence of a definite partial order between two entanglement measures for all quantum states, however, allows for meaningful conceptualization of sensitivity to entanglement, which will be greater for the entanglement measure that produces the larger numerical values. Here, we have investigated the partial orde…Read more
  •  151
    Thermal stability of solitons in protein α-helices
    with James F. Glazebrook
    Chaos, Solitons and Fractals 155 111644. 2022.
    Protein α-helices provide an ordered biological environment that is conducive to soliton-assisted energy transport. The nonlinear interaction between amide I excitons and phonon deformations induced in the hydrogen-bonded lattice of peptide groups leads to self-trapping of the amide I energy, thereby creating a localized quasiparticle (soliton) that persists at zero temperature. The presence of thermal noise, however, could destabilize the protein soliton and dissipate its energy within a finite…Read more
  •  416
    Capacity of conscious agents to perform genuine choices among future alternatives is a prerequisite for moral responsibility. Determinism that pervades classical physics, however, forbids free will, undermines the foundations of ethics, and precludes meaningful quantification of personal biases. To resolve that impasse, we utilize the characteristic indeterminism of quantum physics and derive a quantitative measure for the amount of free will manifested by the brain cortical network. The interac…Read more
  •  254
    Human creativity generates novel ideas to solve real-world problems. This thereby grants us the power to transform the surrounding world and extend our human attributes beyond what is currently possible. Creative ideas are not just new and unexpected, but are also successful in providing solutions that are useful, efficient and valuable. Thus, creativity optimizes the use of available resources and increases wealth. The origin of human creativity, however, is poorly understood, and semantic meas…Read more
  •  36
    Quantum information in neural systems
    Symmetry 13 (5): 773. 2021.
    Identifying the physiological processes in the central nervous system that underlie our conscious experiences has been at the forefront of cognitive neuroscience. While the principles of classical physics were long found to be unaccommodating for a causally effective consciousness, the inherent indeterminism of quantum physics, together with its characteristic dichotomy between quantum states and quantum observables, provides a fertile ground for the physical modeling of consciousness. Here, we …Read more
  •  46
    Virtual reality for neurorehabilitation and cognitive enhancement
    with Iva Georgieva, Zhengya Gong, Vijayakumar Nanjappan, and Georgi V. Georgiev
    Brain Sciences 11 (2): 221. 2021.
    Our access to computer-generated worlds changes the way we feel, how we think, and how we solve problems. In this review, we explore the utility of different types of virtual reality, immersive or non-immersive, for providing controllable, safe environments that enable individual training, neurorehabilitation, or even replacement of lost functions. The neurobiological effects of virtual reality on neuronal plasticity have been shown to result in increased cortical gray matter volumes, higher con…Read more
  •  187
    Quantum transport and utilization of free energy in protein α-helices
    with James F. Glazebrook
    Advances in Quantum Chemistry 82 253-300. 2020.
    The essential biological processes that sustain life are catalyzed by protein nano-engines, which maintain living systems in far-from-equilibrium ordered states. To investigate energetic processes in proteins, we have analyzed the system of generalized Davydov equations that govern the quantum dynamics of multiple amide I exciton quanta propagating along the hydrogen-bonded peptide groups in α-helices. Computational simulations have confirmed the generation of moving Davydov solitons by applied …Read more
  •  247
    Computational capacity of pyramidal neurons in the cerebral cortex
    with Stefan K. Kolev, Eliahu Cohen, and James F. Glazebrook
    Brain Research 1748 147069. 2020.
    The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, respectively. For a proper assessment of the computational capacity of pyramidal neurons, we have analyzed an extensive dataset of three-dimensional digital reconstructions from the…Read more
  •  239
    Launching of Davydov solitons in protein α-helix spines
    with James F. Glazebrook
    Physica E: Low-Dimensional Systems and Nanostructures 124 114332. 2020.
    Biological order provided by α-helical secondary protein structures is an important resource exploitable by living organisms for increasing the efficiency of energy transport. In particular, self-trapping of amide I energy quanta by the induced phonon deformation of the hydrogen-bonded lattice of peptide groups is capable of generating either pinned or moving solitary waves following the Davydov quasiparticle/soliton model. The effect of applied in-phase Gaussian pulses of amide I energy, howeve…Read more
  •  670
    The human mind is constituted by inner, subjective, private, first-person conscious experiences that cannot be measured with physical devices or observed from an external, objective, public, third-person perspective. The qualitative, phenomenal nature of conscious experiences also cannot be communicated to others in the form of a message composed of classical bits of information. Because in a classical world everything physical is observable and communicable, it is a daunting task to explain how…Read more
  •  177
    Probing finite coarse-grained virtual Feynman histories with sequential weak values
    with Eliahu Cohen
    Physical Review A 97 (5): 052102. 2018.
    Feynman's sum-over-histories formulation of quantum mechanics has been considered a useful calculational tool in which virtual Feynman histories entering into a coherent quantum superposition cannot be individually measured. Here we show that sequential weak values, inferred by consecutive weak measurements of projectors, allow direct experimental probing of individual virtual Feynman histories, thereby revealing the exact nature of quantum interference of coherently superposed histories. Becaus…Read more
  •  71
    The quantum physics of synaptic communication via the SNARE protein complex
    with James F. Glazebrook
    Progress in Biophysics and Molecular Biology 135 16-29. 2018.
    Twenty five years ago, Sir John Carew Eccles together with Friedrich Beck proposed a quantum mechanical model of neurotransmitter release at synapses in the human cerebral cortex. The model endorsed causal influence of human consciousness upon the functioning of synapses in the brain through quantum tunneling of unidentified quasiparticles that trigger the exocytosis of synaptic vesicles, thereby initiating the transmission of information from the presynaptic towards the postsynaptic neuron. Her…Read more
  •  130
    This book addresses the fascinating cross-disciplinary field of quantum information theory applied to the study of brain function. It offers a self-study guide to probe the problems of consciousness, including a concise but rigorous introduction to classical and quantum information theory, theoretical neuroscience, and philosophy of the mind. It aims to address long-standing problems related to consciousness within the framework of modern theoretical physics in a comprehensible manner that eluci…Read more
  •  1277
    Quantum no-go theorems and consciousness
    Axiomathes 23 (4): 683-695. 2013.
    Our conscious minds exist in the Universe, therefore they should be identified with physical states that are subject to physical laws. In classical theories of mind, the mental states are identified with brain states that satisfy the deterministic laws of classical mechanics. This approach, however, leads to insurmountable paradoxes such as epiphenomenal minds and illusionary free will. Alternatively, one may identify mental states with quantum states realized within the brain and try to resolve…Read more
  •  100
    In this paper we try to make a clear distinction between quantum mysticism and quantum mind theory. Quackery always accompanies science especially in controversial and still under development areas and since the quantum mind theory is a science youngster it must clearly demarcate itself from the great stuff of pseudo-science currently patronized by the term "quantum mind". Quantum theory has attracted a big deal of attention and opened new avenues for building up a physical theory of mind becaus…Read more
  •  136
    SNARE proteins as molecular masters of interneuronal communication
    with James F. Glazebrook
    Biomedical Reviews 21 17-23. 2010.
    In the beginning of the 20th century the groundbreaking work of Ramon y Cajal firmly established the neuron doctrine, according to which neurons are the basic structural and functional units of the nervous system. Von Weldeyer coined the term “neuron” in 1891, but the huge leap forward in neuroscience was due to Cajal’s meticulous microscopic observations of brain sections stained with an improved version of Golgi’s la reazione nera (black reaction). The latter improvement of Golgi’s technique m…Read more
  •  64
    There are many blank areas in understanding the brain dynamics and especially how it gives rise to consciousness. Quantum mechanics is believed to be capable of explaining the enigma of conscious experience, however till now there is not good enough model considering both the data from clinical neurology and having some explanatory power! In this paper is presented a novel model in defence of macroscopic quantum events within and between neural cells. The beta-neurexin-neuroligin-1 link is claim…Read more
  •  39
    We discuss the multiple pass interferometer setup proposed by Unruh, and clarify some of the fundamental issues linked with complementarity. We explicitly state all mathematical instructions for manipulating the quantum amplitudes and assessing the probability distribution functions. In this respect we show that certain purely math logical limitations (requirement for consistency) prevent one to argue that there is one-to-one corespondence between paths 1 and 2 and the exit gates 10 and 9 ("whic…Read more
  •  65
    In neurophysiology it is widely assumed that our mind operates in millisecond timescale. This view might be wrong, because if consciousness is quantum coherent phenomenon at the level of protein assemblies, then its dynamic timescale can be picosecond one.
  •  80
    The principles of classical physics, including deterministic dynamics and observability of physical states, are incompatible with the existence of unobservable conscious minds that possess free will. Attempts to directly accommodate consciousness in a classical world lead to philosophical paradoxes such as causally ineffective consciousness and possibility of alternate worlds in which functional brain isomorphs behave identically but lack conscious experiences. Here, we show that because Chalmer…Read more