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    Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea
    with B. A. Edwards, D. G. McSharry, S. A. Sands, A. Desai, G. Kehlmann, J. P. Bakker, P. R. Genta, R. L. Owens, D. P. White, A. Wellman, and A. Malhotra
    Copyright © 2014 by the American Thoracic Society. Rationale: A low respiratory arousal threshold is one of several traits involved in obstructive sleep apnea pathogenesis and may be a therapeutic target; however, there is no simple way to identify patients without invasive measurements. Objectives: To determine the physiologic determinates of the ArTH and develop a clinical tool that can identify patients with low ArTH. Methods: Anthropometric data were collected in 146 participants who underwe…Read more
  • Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway
    with P. R. Genta, R. L. Owens, B. A. Edwards, S. A. Sands, J. P. Butler, S. H. Loring, A. Malhotra, A. C. Jackson, D. P. White, and A. Wellman
    The upper airway is often modeled as a Starling resistor, which predicts that flow is independent of inspiratory effort during flow limitation. However, while some obstructive sleep apnea patients exhibit flat, Starling resistor-like flow limitation, others demonstrate considerable negative effort dependence, defined as the percent reduction in flow from peak to mid-inspiration. We hypothesized that the variability in NED could be due to differences in phasic pharyngeal muscle activation between…Read more