Deborah Fox

Calcineurin is a Ca2+/calmodulin‐activated protein phosphatase that is conserved in eukaryotes, from yeast to humans, and is the conserved target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. Genetic studies in yeast and fungi established the molecular basis of calcineurin inhibition by the cyclophilin A–CsA and FKBP12–FK506 complexes. Calcineurin also functions in fungi to control a myriad of physiological processes including cell cycle progression, cation homeostasis, and morphogenesis. Recent investigations into the molecular mechanisms of pathogenesis in Candida albicans and Cryptococcus neoformans, two fungi that cause life‐threatening infections in humans, have revealed an essential role for calcineurin in morphogenesis, virulence, and antifungal drug action. Novel non‐immunosuppressive analogs of the calcineurin inhibitors CsA and FK506 that retain antifungal activity have been identified and hold promise as candidate antifungal drugs. In addition, comparisons of calcineurin function in both fungi and humans may identify fungal‐specific components of calcineurin‐signaling pathways that could be targeted for therapy, as well as conserved elements of calcium signaling events. BioEssays 24:894–903, 2002. © 2002 Wiley Periodicals, Inc.

A dominant strand of second wave feminism, represented in this essay by Firestone, is tied to a belief in technology to achieve reproductive justice, echoing Western somatophobic rationality. As such, it has difficulty formulating a critique of institutionalized reproductive technologies that have the capacity to perpetuate systemic racializing and misogynous violence, and envisioning a philosophy of reproductive justice where care for the body takes central stage. In this essay, we offer a perspective on achieving reproductive justice from an age-old position largely neglected by feminism: that of midwifery. Midwifery has always been wary of technology in the field of reproduction, having first-hand experience with its consequences in birth and pregnancy, and has developed a field of scholarship critiquing its misuse. Simultaneously, midwifery negotiates technology from a position that prioritizes experiential, embodied, and tacit knowledge. Midwifery’s epistemological standpoint is that of a somatophilic rationality of thinking with the body, guarding women and birthing people’s reproductive autonomy through a specific technē that uses both technology and nature. A certain tendency in midwifery is, however, developing more and more towards an anti-technological essentialism. This essay therefore brings into dialogue Firestone’s Marxist women’s liberation through the elimination of biological sex with the help of technology, and midwifery’s somatophilic epistemic standpoint, to develop a feminist rational engagement with nature that can achieve reproductive justice, on the basis of their shared biological materialism.