San Francisco, California, United States of America
  •  4
    Policy driven changes in animal research practices: mapping researchers’ attitudes towards animal-free innovations using the Netherlands as an example
    with S. K. Schoustra, P. H. A. Postma, C. Gräwe, H. van den Elzen, and S. Bressers
    Research Integrity and Peer Review 4 (1). 2019.
    BackgroundReducing the number of animals used in experiments has become a priority for the governments of many countries. For these reductions to occur, animal-free alternatives must be made more available and, crucially, must be embraced by researchers.MethodsWe conducted an international online survey for academics in the field of animal science (N = 367) to explore researchers’ attitudes towards the implementation of animal-free innovations. Through this survey, we address three key questions…Read more
  •  1
    Dopamine genes and nicotine dependence in treatment-seeking and community smokers
    with A. W. Bergen, D. V. Conti, W. Lee, J. Liu, D. Li, N. Guo, Mi H., P. D. Thomas, C. N. Lessov-Schlaggar, R. Krasnow, Y. He, D. Nishita, R. Jiang, J. B. McClure, E. Tildesley, H. Hops, R. F. Tyndale, N. L. Benowitz, C. Lerman, and G. E. Swan
    We utilized a cohort of 828 treatment-seeking self-identified white cigarette smokers to rank candidate gene single nucleotide polymorphisms associated with the Fagerström Test for Nicotine Dependence, a measure of nicotine dependence which assesses quantity of cigarettes smoked and time- and place-dependent characteristics of the respondent's smoking behavior. A total of 1123 SNPs at 55 autosomal candidate genes, nicotinic acetylcholine receptors and genes involved in dopaminergic function, wer…Read more
  •  2
    Nicotinic acetylcholine receptor β2 subunit gene implicated in a systems-based candidate gene study of smoking cessation
    with D. V. Conti, W. Lee, D. Li, J. Liu, P. D. Thomas, A. W. Bergen, G. E. Swan, R. F. Tyndale, N. L. Benowitz, and C. Lerman
    Although the efficacy of pharmacotherapy for tobacco dependence has been previously demonstrated, there is substantial variability among individuals in treatment response. We performed a systems-based candidate gene study of 1295 single nucleotide polymorphisms in 58 genes within the neuronal nicotinic receptor and dopamine systems to investigate their role in smoking cessation in a bupropion placebo-controlled randomized clinical trial. Putative functional variants were supplemented with tagSNP…Read more
  • Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
    with N. Johnson, F. Dudbridge, N. Orr, L. Gibson, M. E. Jones, M. J. Schoemaker, E. J. Folkerd, B. P. Haynes, J. L. Hopper, M. C. Southey, G. S. Dite, C. Apicella, M. K. Schmidt, A. Broeks, L. J. Van'T. Veer, F. Atsma, K. Muir, A. Lophatananon, P. A. Fasching, M. W. Beckmann, A. B. Ekici, S. P. Renner, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, B. Burwinkel, F. Marme, A. Schneeweiss, C. Sohn, P. Guénel, T. Truong, E. Cordina, F. Menegaux, S. E. Bojesen, B. G. Nordestgaard, H. Flyger, R. Milne, M. P. Zamora, J. I. Arias Perez, J. Benitez, L. Bernstein, H. Anton-Culver, A. Ziogas, C. Clarke Dur, H. Brenner, H. Müller, V. Arndt, A. K. Dieffenbach, A. Meindl, J. Heil, C. R. Bartram, R. K. Schmutzler, H. Brauch, C. Justenhoven, Y. D. Ko, H. Nevanlinna, T. A. Muranen, K. Aittomäki, C. Blomqvist, K. Matsuo, T. Dörk, N. V. Bogdanova, N. N. Antonenkova, A. Lindblom, A. Mannermaa, V. Kataja, V. M. Kosma, J. M. Hartikainen, G. Chenevix-Trench, J. Beesley, A. H. Wu, C. C. Tseng, and D. Lambrechts
    INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism, which maps to the CYP3A locus, was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.METHODS: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Geno…Read more
  •  1
    Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: A case-control study
    with N. Johnson, F. Dudbridge, N. Orr, L. Gibson, M. E. Jones, M. J. Schoemaker, E. J. Folkerd, B. P. Haynes, J. L. Hopper, M. C. Southey, G. S. Dite, C. Apicella, M. K. Schmidt, A. Broeks, L. J. Van'T. Veer, F. Atsma, K. Muir, A. Lophatananon, P. A. Fasching, M. W. Beckmann, A. B. Ekici, S. P. Renner, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, B. Burwinkel, F. Marme, A. Schneeweiss, C. Sohn, P. Guénel, T. Truong, E. Cordina, F. Menegaux, S. E. Bojesen, B. G. Nordestgaard, H. Flyger, R. Milne, M. P. Zamora, J. I. A. Perez, J. Benitez, L. Bernstein, H. Anton-Culver, A. Ziogas, C. C. Dur, H. Brenner, H. Müller, V. Arndt, A. K. Dieffenbach, A. Meindl, J. Heil, C. R. Bartram, R. K. Schmutzler, H. Brauch, C. Justenhoven, Y. D. Ko, H. Nevanlinna, T. A. Muranen, K. Aittomäki, C. Blomqvist, K. Matsuo, T. Dörk, N. V. Bogdanova, N. N. Antonenkova, A. Lindblom, A. Mannermaa, V. Kataja, V. M. Kosma, J. M. Hartikainen, G. Chenevix-Trench, J. Beesley, A. H. Wu, C. C. Tseng, and D. Lambrechts
    © 2014 Johnson et al.Introduction: We have previously shown that a tag single nucleotide polymorphism, which maps to the CYP3A locus, was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Associ…Read more