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    Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials
    with Beitler Jr, B. T. Thompson, M. A. Matthay, D. Talmor, K. D. Liu, H. Zhuo, R. G. Spragg, and A. Malhotra
    © 2015 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. Objectives: Pulmonary dead-space fraction is one of few lung-specific independent predictors of mortality from acute respiratory distress syndrome. However, it is not measured routinely in clinical trials and thus altogether ignored in secondary analyses that shape future research directions and clinical practice. This study sought to validate an estimate of dead-space fraction for use in secondary analyses of clinic…Read more