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    Heinrich von Kleist: The Biography (review)
    with Jeffrey L. High
    The European Legacy 28 (2): 217-220. 2022.
    Ten years after the appearance of Günter Blamberger’s award-winning Heinrich von Kleist. Biographie in the original German, the English translation by Sebastian Goth and Kelly Kawar appeared in 202...
  •  3
    Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2
    with X. Liang, H. C. Chien, S. W. Yee, M. M. Giacomini, M. Piao, J. Hao, J. Twelves, E. I. Lepist, A. S. Ray, and K. M. Giacomini
    © 2015 American Chemical Society.The biguanide metformin is widely used as first-line therapy for the treatment of type 2 diabetes. Predominately a cation at physiological pH's, metformin is transported by membrane transporters, which play major roles in its absorption and disposition. Recently, our laboratory demonstrated that organic cation transporter 1, OCT1, the major hepatic uptake transporter for metformin, was also the primary hepatic uptake transporter for thiamine, vitamin B1. In this …Read more
  •  3
    Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin
    with X. Liang, S. W. Yee, E. G. Geier, S. L. Stocker, L. Chen, and K. M. Giacomini
    Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics.Metformin, the most widely prescribed antidiabetic drug, requires transporters to enter tissues involved in its pharmacologic action, including liver, kidney, and peripheral tissues. Organic cation transporter 3, expressed ubiquitously, transports metformin, but its in vivo role in metformin response is not known. Using Oct3 knockout mice, the role of the transporter in metformin pharmacokinetics and pharmaco…Read more
  •  1
    New insight into the role of MMP14 in metabolic balance
    with H. Mori, R. Bhat, A. Bruni-Cardoso, D. M. Jorgens, K. Coutinho, K. Louie, B. B. Bowen, J. L. Inman, V. Tecca, S. J. Lee, S. Becker-Weimann, T. Northen, M. Seiki, A. D. Borowsky, M. Auer, and M. J. Bissell
    © 2016 Mori et al.Membrane-anchored matrix metalloproteinase 14 is involved broadly in organ development through both its proteolytic and signal-transducing functions. Knockout of Mmp14 in mice results in a dramatic reduction of body size and wasting followed by premature death, the mechanism of which is poorly understood. Since the mammary gland develops after birth and is thus dependent for its functional progression on systemic and local cues, we chose it as an organ model for understanding w…Read more