Fiorela Alassia

According to process ontology in the philosophy of biology, the living world is better understood as processes rather than as substantial individuals. Within this perspective, an organism does not consist of a hierarchy of structures like a machine, but rather a dynamic hierarchy of processes, dynamically maintained and stabilized at different time scales. With this respect, two processual approaches on enzymes by Stein (Hyle Int J Philos Chem 10(4):5–22, 2004, Process Stud 34:62–80, 2005, Found Chem 8:3–29, 2006) and by Guttinger (Everything Flows: Towards a Processual Philosophy of Biology, Oxford University Press, Oxford, 2018) allows to think of macromolecules as relational and processual entities. In this work, I propose to extend their arguments to another case study within the biochemical domain, which is the case of ligand receptors and receptor-mediated biosignaling. The aim of this work is to analyze the case of G Protein-Coupled Receptors and biosignaling under the consideration of a processual ontology. I will defend that the processual ontology framework is adequate for the biochemical domain and that it allows accounting for the current biochemical knowledge related to the case study.

According to process ontology in the philosophy of biology, the living world is better understood as processes rather than as substantial individuals. Within this perspective, an organism does not consist of a hierarchy of structures like a machine, but rather a dynamic hierarchy of processes, dynamically maintained and stabilized at different time scales. With this respect, two processual approaches on enzymes by Stein (Hyle Int J Philos Chem 10(4):5–22, 2004, Process Stud 34:62–80, 2005, Found Chem 8:3–29, 2006) and by Guttinger (Everything Flows: Towards a Processual Philosophy of Biology, Oxford University Press, Oxford, 2018) allows to think of macromolecules as relational and processual entities. In this work, I propose to extend their arguments to another case study within the biochemical domain, which is the case of ligand receptors and receptor-mediated biosignaling. The aim of this work is to analyze the case of G Protein-Coupled Receptors and biosignaling under the consideration of a processual ontology. I will defend that the processual ontology framework is adequate for the biochemical domain and that it allows accounting for the current biochemical knowledge related to the case study.

Biological macromolecules, considered as the items of the biochemical domain, are typically conceived under the ontological category of substantial individuals. In this paper, I will argue that the philosophical framework of process ontology, according to which the living world is not populated by individuals but by a dynamic hierarchy of processes, is more adequate to account for the structure and functioning of macromolecules. In particular, I will analyze its application to the phenomenon of cell signaling and to one of its key concepts, cell receptors. Current knowledge in biochemistry allows us to conceive receptors as processual and dynamic entities, relationally stabilized and not separated from the biochemical phenomenon of which they are part.

In this paper we will briefly explain the context in which the appropriation of 500 children occurred during the most recent Argentinian dictatorship, in order to analyze the political demand of identity restitution of these people. We will describe the phenomenon of restitution that took place thanks to the strategy of Abuelas de Plaza de Mayo, and we will analyze both the role of genetics on the restitution as well as some criticisms to a notion of biological identity considered to emerge from it. We will situate those criticisms in the philosophical debate over personal identity. The main purpose of this paper is to offer two arguments against an alleged genetic notion of personal identity. Firstly, a theoretical argument presents reasons on the basis of contemporary biological knowledge and, secondly, a practical argument refers to the productive role of biotechnologies. Finally, we will discuss some problems that arise from the criticisms themselves in order to give reasons for a defense of the restitution demand.

RESUMEN La postulación de la existencia de receptores bioquímicos permite brindar una explicación satisfactoria para muchos procesos biológicos a nivel celular, como, por ejemplo, el mecanismo de acción de la mayoría de las drogas de acción específica. No obstante, el concepto de receptor fue considerado durante mucho tiempo como carente de referente objetivo, e incluso avanzada la segunda mitad del siglo XX aún existía escepticismo acerca de su existencia. A partir del debate filosófico entre realistas y antirrealistas científicos, indagaremos si la cuestión del realismo permite arrojar luz sobre la historia del concepto de receptor bioquímico. Evaluaremos qué posiciones particulares en el marco del debate permiten comprender tanto la evolución del concepto de receptor como la práctica científica sobre los receptores. Argumentaremos que el caso de los receptores puede ser elucidado aceptando un realismo científico de entidades que considera la manipulabilidad como criterio de existencia -siguiendo a Ian Hacking-. Guiará nuestro trabajo una pregunta estrictamente filosófica: ¿existen los receptores bioquímicos? ABSTRACT The postulation of the existence of biochemical receptors provides a satisfactory explanation for many biological processes at the cellular level, such as the mechanisms of action of most drugs with specific action. However, the concept of receptor was long considered as lacking an objective referent, and even into the second half of the 20th century, there was still skepticism about its existence. By means of the philosophical debate between scientific realists and anti-realists, we will investigate whether the question of realism can shed light on the history of the concept of biochemical receptor. We will evaluate which particular positions within the debate allow us to understand both the evolution of the concept of receptor and the scientific practice on receptors. We will argue that the case of receptors can be elucidated by accepting a scientific realism of entities, which considers manipulability as a criterion of existence -following Ian Hacking-. Our work will be guided by a strictly philosophical query: Do biochemical receptors exist?

In this paper we will argue that the identity of the entities that inhabit the nanoworld is a contextual identity. To defend that, we will analyse the so-called “biological” identity and the “synthetic” identity of nanomaterials. From this analysis, we will claim that nano-individuals (entities that show an intermediate nature between individuals and stuff), can be adequately understood from the perspective of a processual ontology. With that, we intend to contribute to the philosophical understanding of the ontology of the nano-domain.

La relevancia del estudio de las diferencias individuales biológicas en relación con la salud ha ido aumentando progresivamente, y el auge actual de la medicina personalizada es un ejemplo de ello. En este campo, el conjunto único de características de cada paciente individual es la base para diagnósticos y tratamientos personalizados. El objetivo de este trabajo es analizar y definir el problema de la individualidad biológica en medicina, La individualidad biológica se refiere a la singularidad biológica de cada individuo humano y su impacto en la toma de decisiones clínicas las propiedades de los pacientes de ser biológicamente únicos en un modo que atañe a la medicina, en tanto que tiene un impacto en la evaluación y toma de decisiones clínicas respecto del estado de salud del paciente individual. Se analizará este problema en relación con las categorías generales en medicina, centrándose en la medicina basada en evidencia, los ensayos clínicos aleatorizados y la definición de valores de referencia en el laboratorio clínico. Se argumentará que el problema de la individualidad biológica en relación con las categorías generales en salud es fundamentalmente un problema epistemológico relacionado con la validación externa de la evidencia clínica. Además, se explorará cómo la individualización de la medicina, cuyo exponente actual es la medicina personalizada, representa un intento de resolver el problema de la individualidad biológica señalado anteriormente. No obstante, en este contexto también se plantean desafíos de naturaleza tanto epistemológica como metafísica, estos últimos relacionados con la definición de salud y enfermedad.