Houston, Texas, United States of America
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    Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes
    with S. M. Glasgow, W. Zhu, C. C. Stolt, T. W. Huang, J. J. LoTurco, J. L. Neul, M. Wegner, C. Mohila, and B. Deneen
    Lineage progression and diversification is regulated by the coordinated action of unique sets of transcription factors. Oligodendrocytes and astrocytes comprise the glial sub-lineages in the CNS, and the manner in which their associated regulatory factors orchestrate lineage diversification during development and disease remains an open question. Sox10 and NFIA are key transcriptional regulators of gliogenesis associated with OL and AS. We found that NFIA inhibited Sox10 induction of OL differen…Read more