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    Cobalt Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency
    with I. Barr, S. H. Weitz, T. Atkin, P. Hsu, M. Karayiorgou, J. A. Gogos, and S. Weiss
    © 2015 Elsevier Ltd All rights reserved.Summary Processing of microRNA primary transcripts is highly regulated and defects in the processing machinery play a key role in many human diseases. In 22q11.2 deletion syndrome, heterozygous deletion of DiGeorge critical region gene 8 causes a processing deficiency, which contributes to abnormal brain development. The DGCR8 protein is the RNA-binding partner of Drosha RNase, both essential for processing canonical pri-miRNAs. To identify an agent that c…Read more