Hélio Silva

O presente artigo pretende sublinhar, na forma de breves apontamentos gerais, os contornos mais amplos da crítica de Honneth a alguns aspectos do pensamento habermasiano. Tal crítica é norteada especialmente por uma investigação dos critérios morais e normativos das lutas sociais que Honneth recupera, por meio de uma apropriação crítica do pensamento do jovem Hegel. O ponto central defendido por Honneth é que as possibilidades da experiência interativo-comunicativa não podem ser resumidas ou tomadas exclusivamente na interação linguística, nem mesmo esta última pode ser perseguida em seu aspecto ideal, sem a pressuposição dos contextos conflituosos nos quais ela sempre está inserida.

The aim of this work is to present the thesis “On the Ontogenetic Evolution of the Human Embryo in its Relations with Phylogenesis,” by Affonso Regulo de Oliveira Fausto, published in Brazil in 1890. To our knowledge, it was one of the first Brazilian academic works focused specifically on evolution. It was also the first doctoral thesis that addressed the topic of recapitulation in order to analyze what was then called the progressive evolution of the human species in tandem with the embryological development of the individuals that would constitute the Brazilian “type.” In the present work, we analyze the author’s thesis in relation to its sources, concepts, as well as the country’s political context at the time of its publication. Fausto’s text, in which he explicitly recognized the influence of Ernst Haeckel’s recapitulation theory, represents a window to understand better a concept of nation based on science and on the idea of inexorable progress that was accepted in Brazil at the end of the nineteenth century.

Resumo: Eu mostro neste artigo que Schopenhauer e Bergson, mesmo abordando o problema da ação livre a partir de pontos de vista filosóficos opostos, concordam em caracterizar as ações humanas de um modo que não é nem determinista, nem compatível com a tese do liberum arbitrium. Schopenhauer, embora equivocadamente tente demonstrar a necessidade de tais ações, é obrigado a reconhecê-las como grundlos e imprevisíveis, enquanto Bergson, embora pretenda mostrá-las como sendo livres, ao final admite que elas não são objeto de uma escolha através da razão. Essa coincidência inesperada entre ambos os filósofos, a respeito do problema da liberdade da ação humana, será explorada neste texto.: I show in this paper that Schopenhauer and Bergson, although approaching the problem of free action from opposed philosophical standpoints, agree in characterizing human actions in a way which is neither determinist nor compatible with the liberum arbitrium thesis. Schopenhauer, although mistakenly trying to demonstrate the necessity of such actions, is obliged to recognize then as grundlos and unpredictable. Bergson, although intending to show such actions as free, in the end admits that they are not a matter of a reasonable choice. It is this unexpected agreement between both philosophers on the problem of the freedom of human action that will be explored in this paper.

Pretendemos neste artigo examinar a aparente incompatibilidade entre a concepção, exposta na terceira Crítica kantiana, do jogo livre ou harmonia entre as faculdades da Imaginação e do Entendimento e a Dedução Transcendental das Categorias da primeira das Críticas kantianas, na medida em que a primeira parece afirmar que a Imaginação pode apreender “sem conceitos” um objeto intuído, ao passo que a última parece submeter todas estas apreensões à posse a priori de um conceito. De modo a realizar este exame, vamos considerar as posições assumidas por alguns dos mais proeminentes interpretes da filosofia de Kant

O objetivo deste texto é mobilizar a noção de sofrimento social como uma das dimensões estruturantes do fenômeno da pobreza. Para realizar esse trajeto, são apresentados, inicialmente, os contornos mais decisivos do sofrimento social que podem ser mobilizados para realizar o objetivo proposto. Em seguida, apresenta-se uma noção de pobreza construída a partir da crítica à tendência de aproximação, frequente nas poverty theories, entre pobreza e mínimo. Finalmente, no terceiro momento, diferentes níveis de pobreza são articulados às diferentes formas de sofrimento social, com especial atenção para experiências de humilhação.

This essay aim to highlight some tensions existing in Rousseau's work that forwards a reading of his work from the point of view of the notion of a reluctant Enlightenment. The avail of this notion seems relevant to the extent that some principles guiding the Rousseau’s work are constantly confronted by the difficulties presented by History. Thus, Rousseau must manage deal with tensions which emerges from inside of his thought, such as: reason and sensibility, public education and private education, reason and history, popular sovereignty and lawgiver, among others

Helio Tedesco-Silva Jr, Claudia Rosso Felipe, Tainá Veras de Sandes Freitas, Marina Pontello Cristeli, Carolina Araújo Rodrigues, José Osmar Medina PestanaNephrology Division, Hospital do Rim e Hipertensão, Universidade Federal de São Paulo, Brazil: Everolimus is an immunosuppressive agent used for the prophylaxis of acute rejection after kidney transplantation. Everolimus inhibits the activity of the serine/threonine kinase mammalian target of rapamycin, a key enzyme that controls cell growth and metabolism, producing cell cycle arrest from the G1 to S phase. As a consequence, everolimus has antiproliferative and antineoplastic effects. Everolimus is a drug with a narrow therapeutic index. The pharmacokinetics of everolimus indicates a need for twice-daily dosing. Intra- and interindividual variability and drug–drug interactions suggest the need for therapeutic drug monitoring to maximize the efficacy/toxicity ratio. The good correlation between exposure and trough concentration indicates that monitoring of everolimus trough concentrations is an adequate strategy after kidney transplantation. Everolimus is indicated for low- to moderate-risk de novo kidney transplant candidates. There are no conclusive studies thus far indicating that everolimus can be used in high-risk patients, such as sensitized patients, retransplants, and African Americans. In de novo kidney transplant recipients, the recommended initial dose of everolimus is 0.75 mg twice daily, adjusted to maintain blood trough concentrations of 3–8 ng/mL, in combination with progressive reduction in blood trough cyclosporine concentrations to 25–50 ng/mL. In combination with reduced trough blood tacrolimus concentrations of 4–7 ng/mL the recommended initial dose of everolimus is 1.5 mg twice daily, adjusted to maintain trough blood concentrations of 3–8 ng/mL. Everolimus can also be used as a conversion strategy, mainly to preserve renal function and to manage patients with malignancy. There is no definition of the ideal strategy for conversion, ie, abrupt or sequential, initial dose of everolimus, or target therapeutic trough blood concentrations. Intensive monitoring is recommended after conversion, especially for acute rejection and proteinuria. Because mTOR is ubiquitous and central to many intracellular processes, an array of adverse reactions may occur, including delayed tissue regeneration, proteinuria, dyslipidemia, diabetes, myelosuppression, infertility, ovarian cysts, and mouth ulcers. Because long-term benefits are the goal of any immunosuppressive strategy, further investigations aiming to understand, prevent, and manage everolimus-related adverse reactions are necessary to mitigate the risks and improve tolerability, allowing maximization of all the benefits of this drug.Keywords: everolimus, immunosuppression, mTOR inhibitors, calcineurin inhibitors, kidney transplantation.