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    Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity
    with Sarah K. Deng and Lorraine S. Symington
    Bioessays 37 (3): 305-313. 2015.
    Replication protein A (RPA) is the main eukaryotic single‐stranded DNA (ssDNA) binding protein, having essential roles in all DNA metabolic reactions involving ssDNA. RPA binds ssDNA with high affinity, thereby preventing the formation of secondary structures and protecting ssDNA from the action of nucleases, and directly interacts with other DNA processing proteins. Here, we discuss recent results supporting the idea that one function of RPA is to prevent annealing between short repeats that ca…Read more