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    Overexpression of the Na + /K + ATPase α2 But Not α1 isopathological cardiac hypertrophy and remodelingform Attenuates
    with R. N. Correll, P. Eder, A. R. Burr, S. Despa, D. M. Bers, and J. D. Molkentin
    © 2013 American Heart Association, Inc.Rationale: The Na + /K + ATPase directly regulates intracellular Na + levels, which in turn indirectly regulates Ca2 + levels by proximally controlling flux through the Na + /Ca2 + exchanger. Elevated Na + levels have been reported during heart failure, which permits some degree of reverse-mode Ca2 + entry through NCX1, as well as less efficient Ca2 + clearance. Objective: To determine whether maintaining lower intracellular Na + levels by NKA overexpressio…Read more