Jan Koster

Cancers often express hundreds of genes otherwise specific to germ cells, the germline/cancer (GC) genes. Here, we present and discuss the hypothesis that activation of a “germline program” promotes cancer cell malignancy. We do so by proposing four hallmark processes of the germline: meiosis, epigenetic plasticity, migration, and metabolic plasticity. Together, these hallmarks enable replicative immortality of germ cells as well as cancer cells. Especially meiotic genes are frequently expressed in cancer, implying that genes unique to meiosis may play a role in oncogenesis. Because GC genes are not expressed in healthy somatic tissues, they form an appealing source of specific treatment targets with limited side effects besides infertility. Although it is still unclear why germ cell specific genes are so abundantly expressed in cancer, from our hypothesis it follows that the germline's reproductive program is intrinsic to cancer development.

In a nutshell, this dissertation builds a bridge between an informal psychological model of emotions on the one hand, and implementation of emotions in robots and virtual characters on the other hand. This is done by formalizing a psychological model of emotions. With that we1 mean translating the concepts used in the psy- chological model to a logical language with unambiguous semantics. The resulting formalization of emotions will give rise to theorems that can be proved to be true. These theorems are properties of the formal model and can be checked against the original psychological model of emotions. If they match, this will mean that the formalization is truthful with respect to the psychological model. The description of the model of emotions in this formal language can then be used as a foundation for implementing emotions in robots and virtual characters