• SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion
    with B. Ren, Z. Azzegagh, A. M. Jaramillo, Y. Zhu, A. Pardo-Saganta, R. Bagirzadeh, Flores Jr, W. Han, Y. -J. Tang, J. Tu, D. M. Alanis, C. M. Evans, M. Guindani, P. A. Roche, J. Rajagopal, C. W. Davis, M. J. Tuvim, and B. F. Dickey
    Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in…Read more
  • SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion
    with B. Ren, Z. Azzegagh, A. M. Jaramillo, Y. Zhu, A. Pardo-Saganta, R. Bagirzadeh, Flores Jr, W. Han, Y. J. Tang, J. Tu, D. M. Alanis, C. M. Evans, M. Guindani, P. A. Roche, J. Rajagopal, C. W. Davis, M. J. Tuvim, and B. F. Dickey
    © 2015 The Author.Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indi…Read more