• Smith College
    Department of Philosophy
    Other faculty (Postdoc, Visiting, etc)
Northampton, Massachusetts, United States of America
Areas of Interest
17th/18th Century Philosophy
  •  3
    Different profiles of carcinogen exposure in Chinese compared with US cigarette smokers
    with N. L. Benowitz, Q. Gan, M. L. Goniewicz, W. Lu, X. Li, Jacob P., and S. Glantz
    © 2015, BMJ Publishing Group. All rights reserved.Background Differences in carcinogen exposure from different cigarette products could contribute to differences in smoking-associated cancer incidence among Chinese compared with US smokers. Methods Urine concentrations of metabolites of nicotine, the tobacco-specific nitrosamine 4--1--1-butanol, and polycyclic aromatic hydrocarbon metabolites were compared in 238 Chinese and 203 US daily smokers. Results Comparing Chinese versus US smokers, dail…Read more
  •  5
    Loss of inositol phosphorylceramide sphingolipid mannosylation induces plant immune responses and reduces cellulose content in arabidopsis
    with L. Fang, T. Ishikawa, E. A. Rennie, G. M. Murawska, J. Lao, J. Yan, A. Y. L. Tsai, E. E. K. Baidoo, J. D. Keasling, T. Demura, M. Kawai-Yamada, H. V. Scheller, and J. C. Mortimer
    © 2016 American Society of Plant Biologists. All rights reserved.Glycosylinositol phosphorylceramides are a class of glycosylated sphingolipids found in plants, fungi, and protozoa. These lipids are abundant in the plant plasma membrane, forming; 25% of total plasma membrane lipids. Little is known about the function of the glycosylated headgroup, but two recent studies have indicated that they play a key role in plant signaling and defense. Here, we show that a member of glycosyltransferase fam…Read more
  •  1
    Polarity reveals intrinsic cell chirality
    with A. Van Keymeulen, N. M. Wakida, P. Carlton, M. W. Berns, and H. R. Bourne
    Like blood neutrophils, dHL60 cells respond to a uniform concentration of attractant by polarizing in apparently random directions. How each cell chooses its own direction is unknown. We now find that an arrow drawn from the center of the nucleus of an unpolarized cell to its centrosome strongly predicts the subsequent direction of attractant-induced polarity: Of 60 cells that polarized in response to uniform f-Met-Leu-Phe, 42 polarized to the left of this arrow, 6 polarized to the right, and 12…Read more
  •  1
    A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection
    with W. Deng, B. G. Gowen, L. Zhang, L. Wang, S. Lau, A. Iannello, T. L. Rovis, N. Xiong, and D. H. Raulet
    Immune cells, including natural killer cells, recognize transformed cells and eliminate them in a process termed immunosurveillance. It is thought that tumor cells evade immunosurveillance by shedding membrane ligands that bind to the NKG2D-activating receptor on NK cells and/or Tcells, and desensitize these cells. In contrast, we show that in mice, a shed form of MULT1, a high-affinity NKG2D ligand, causes NK cell activation and tumor rejection. Recombinant soluble MULT1 stimulated tumor reject…Read more
  •  1
    P2-type Na2/3Fe1/3Mn2/3O2 was prepared by means of solid-state reaction. Its electrochemical properties as a cathode for sodium-ion batteries were investigated in the 1.5-4.3 V range vs. Na metal. This material delivers an initial discharge capacity as high as 193 mAh/g and maintains 153 mAh/g in 40 cycles. Such a high reversible capacity is achieved because both Mn3+/Mn4+ and Fe3+/ Fe4+ become active in the studied voltage range, as confirmed by X-ray absorption spectroscopy. The thermal stabil…Read more
  •  3
    © the Partner Organisations 2014.An in-depth understanding of Na2Ti3O7 as a Na-ion battery anode is reported. The battery performance is enhanced by carbon coating, due to increased electronic conductivity and reduced solid electrolyte interphase formation. Ti4+ reduction upon discharge is demonstrated using in situ XAS. The self-relaxation behaviour of the fully intercalated phase is revealed. This journal is.
  •  5
    An association analysis between psychophysical characteristics and genome-wide gene expression changes in human adaptation to the extreme climate at the Antarctic Dome Argus
    with C. Xu, X. Ju, D. Song, F. Huang, D. Tang, Z. Zou, C. Zhang, T. Joshi, L. Jia, W. Xu, K. F. Xu, Q. Wang, Y. Xiong, Z. Guo, X. Chen, Y. Zhong, Y. Zhu, Y. Peng, L. Wang, X. Zhang, R. Jiang, D. Li, T. Jiang, D. Xu, and C. Jiang
    © 2015 Macmillan Publishers Limited All rights reserved. Genome-wide gene expression measurements have enabled comprehensive studies that integrate the changes of gene expression and phenotypic information to uncover their novel associations. Here we reported the association analysis between psychophysical phenotypes and genome-wide gene expression changes in human adaptation to one of the most extreme climates on Earth, the Antarctic Dome Argus. Dome A is the highest ice feature in Antarctica, …Read more