•  50
    The Quest for System-Theoretical Medicine in the COVID-19 Era
    with Felix Tretter, Olaf Wolkenhauer, Michael Meyer-Hermann, Sara Green, James Marcum, and Wolfram Weckwerth
    Frontiers in Medicine 8 640974. 2021.
    Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The C…Read more
  •  27
    Antagonistic Redundancy -- A Theory of Error-Correcting Information Transfer in Organisms
    with Bernhard O. Boehm
    In Robert Trappl (ed.), Cybernetics and Systems 2004. pp. 225-30. 2004.
    Living organisms are exposed to numerous influencing factors. This holds also true for their infrastructures that are processing and transducing information like endocrine networks or nerval channels. Therefore, the ability to compensate for noise is crucial for survival. An efficient mechanism to neutralise disturbances is instantiated in form of parallel complementary communication channels exerting antagonistic effects at their common receivers. Different signal processing types share the abi…Read more
  •  22
    Seit wenigen Jahren erfreuen sich in den Lebenswissenschaften mehrere Theorien eines immer weitergehenden Einflusses, die unter Etikettierungen wie Systembiologie, Netzwerktheorie oder Signalomics nur scheinbar unabhängige Herangehensweisen an komplexe Zusammenhänge darstellen. Navigation ist der übergreifende Gedanke, der so unterschiedliche Gebiete wie Regelungstheorie, Entscheidungstheorie und Systemwissenschaft verbindet. Navigation als Lage- und Kursbestimmung nebst den zugehörigen Signalve…Read more