John Nelson

St Marys Seminary
  •  5
    Cutaneous effects of cryogen spray cooling on in vivo human skin
    with N. Datrice, J. Ramirez-San-Juan, R. Zhang, A. Meshkinpour, G. Aguilar, and K. M. Kelly
    BACKGROUND: Despite widespread clinical use of cryogen spray cooling in conjunction with laser dermatologic surgery, in vivo cutaneous effects have not been systematically evaluated. OBJECTIVE: The authors characterize the in vivo cutaneous effects for Fitzpatrick skin types I through VI after CSC exposures of varying spurt durations and spurt delivery patterns. METHODS AND MATERIALS: Twenty-seven normal human subjects were exposed to single cryogen spurts from 10 to 80 milliseconds, and multipl…Read more
  •  2
    Background and Objective: Although cryogen spray cooling is used to minimize the risk of epidermal damage during laser dermatologic surgery, concern has been expressed that CSC may induce cryo-injury. The objective of this study is to measure temperature variations at the epidermal-dermal junction in ex vivo human skin during three clinically relevant multiple cryogen spurt-laser pulse sequences. Study Design/Materials and Methods: The epidermis of ex vivo human skin was separated from the dermi…Read more
  •  4
    Background: Optical Doppler tomography combines laser Doppler flowmetry with optical coherence tomography to obtain high-resolution images of blood flow in human skin in situ and in real time. Observations: We present a case in which ODT was used on a patient with a port-wine stain birth-mark to document the change of blood flow in response to laser therapy. It might be possible to use ODT blood flow measurements in situ to assist in assessing the efficacy of laser PWS therapy. If partial restor…Read more