John Smith

The backlash against the Olympic Games reflects the failure of the major global institutions in dealing with the social and ethical consequences of globalisation in areas such as the environment, poverty, terrorism and natural disasters. Disillusionment with the Olympic Games mirrors the disenchantment with the perceived values of globalisation, including winning at any price, commercial exploitation by MNCs, intense national rivalry, cronyism, cheating and corruption and the competitive advantage of advanced nations. How could the Olympic Movement reverse this perception? The most important change would be in the area of leadership. Revitalising the Olympic spirit will require a revolution at the IOC. Character, credibility and communication will be the critical success factors. Before appointing the next President of the IOC, there is an exciting opportunity to reconceptualise the Games as a platform for building a framework of global values to counter-balance the naked economic priorities currently dictating the pattern of globalisation. In reinventing the Olympic Games, it is important to recognise that the modern Games are based upon an anachronism. The idea that amateur sport is both the key to individual moral development and world harmony is largely an invention of the British aristocracy, whereas the original Greek Games not only celebrated the classical ideal of `a sound mind in a sound body', but also involved professional athletes and commercial activity. In making the Olympic Charter relevant to the 21st century, and in making the Olympics more than just a speculator sporting event, there is a strong case for the Games to include a wider spectrum of activities, including arts programs and policy forums, which address the well-being of all humanity in a competitive global economy.

DNA base pairing has been used for many years to direct the arrangement of inorganic nanocrystals into small groupings and arrays with tailored optical and electrical properties. The control of DNA-mediated assembly depends crucially on a better understanding of three-dimensional structure of DNA-nanocrystal-hybridized building blocks. Existing techniques do not allow for structural determination of these flexible and heterogeneous samples. Here we report cryo-electron microscopy and negative-staining electron tomography approaches to image, and three-dimensionally reconstruct a single DNA-nanogold conjugate, an 84-bp double-stranded DNA with two 5-nm nanogold particles for potential substrates in plasmon-coupling experiments. By individual-particle electron tomography reconstruction, we obtain 14 density maps at ~ 2-nm resolution. Using these maps as constraints, we derive 14 conformations of dsDNA by molecular dynamics simulations. The conformational variation is consistent with that from liquid solution, suggesting that individual-particle electron tomography could be an expected approach to study DNA-assembling and flexible protein structure and dynamics.