L. Klaus

The COVID-19 pathogen led to a fast expanding pandemic because it proved lethal in certain populations but could be transmitted by persons who appeared healthy. As a result, researchers came under unprecedented time pressure to develop a vaccine. This case study focuses on the first COVID-19 vaccine, which was approved for use in humans, known as Comirnaty, the BioNTech-Pfizer COVID-19 vaccine or Vaccine BNT162b2. With the benefit of hindsight, we show how close collaboration with regulators and trust-based decisions meant that the race for a COVID-19 vaccine was won without purposefully infecting healthy participants with an infectious agent that can cause severe illness or death and for which no rescue therapy had existed.

George Spencer Brown, a polymath and author of Laws of Form, brought together mathematics, electronics, engineering and philosophy to form an unlikely bond. This book investigates Design with the NOR, the title of the yet unpublished 1961 typescript by Spencer Brown. The typescript formed through the author's experiences as technical engineer and developer of a new form of switching algebra for Mullard Equipment LTD., a British manufacturer of electronic components. Related essays contextualise the typescript drawing on a variety of backgrounds from mathematics and engineering to philosophy and sociology.

Cultural and biographical influences on the expression of emotions manifest themselves in so-called “display rules.” These rules determine the time, intensity, and situations in which an emotion is expressed. To date, only a small number of empirical studies deal with this transformation of how migrants, who are faced with a new culture, may change their emotional expression. The present, cross-sectional study focuses on changes in anger expression as part of a complex acculturation process among Iranian migrants. To this end, Iranian citizens in Iran, German citizens, and Iranian migrants in Germany were compared in terms of anger expression behavior and acculturation strategy was assessed among the migrants, using the Frankfurt Acculturation Scale. A questionnaire developed in a preliminary study was used to measure anger expression via subjective anger experience and anger expression within 16 hypothetical situations. Multivariate Analyses of Variance revealed that Iranians and Iranian migrants reported higher anger experience ratings than Germans and directed their anger more often inward. Further findings suggest that transformation processes may have affected Iranian migrants in terms of suppressed anger : Iranian migrants with a higher orientation toward German culture reported lower average anger-in scores. These results suggest that there was different emotional expression among Iranian migrants, depending on their acculturation. The results provide new insight into socio-cultural and individual adjustment processes.

Mild signs of postpartum depression or anxiety are present in up to half of all new mothers. However, the impact of having the “baby blues” on infant development remains largely unknown. The current study explores a potential relation between mother’s self-reported depression or anxiety symptoms and infant’s motor development in a longitudinal sample of 50 mother-infant dyads. Further, we examine whether engaging in fetal kick counting during pregnancy may reduce maternal psychopathology symptoms and thereby positively influence infant motor development and parent-child engagement during the first months of life. We hypothesized that subclinical maternal psychopathology would negatively impact infant motor development, and that completing a fetal kick count activity during the third trimester would reduce overall signs of maternal psychopathology. Results only partially support these hypotheses. Postpartum maternal anxiety seems to negatively affect the emergence of infants’ fine motor skills. However, engaging in fetal kick counting during pregnancy did not reduce maternal depression or anxiety symptoms. Nevertheless, preliminary evidence suggests that engaging in fetal kick counting may impact early child development by altering the mother’s attitudes toward the child. Future research is needed to examine the value of this low-cost intervention strategy more closely.

The independence of research is a key strategic issue of modern societies. Dealing with it appropriately poses legal, economic, political, social and cultural problems for society, which have been studied by the corresponding disciplines and are increasingly the subject of reflexive discourses of scientific communities. Unfortunately, problems of independence are usually framed in disciplinary contexts without due consideration of other perspectives’ relevance or possible contributions. To overcome these limitations, we review disciplinary perspectives and findings on the independence of research and identify interdisciplinary prospects that could inform a research programme.

Since a number of years, popular and scientific interest in resilience is rapidly increasing. More recently, also neuroscientific research in resilience and the associated neurobiological findings is gaining more attention. Some of these neuroscientific findings might open up new measures to foster personal resilience, ranging from magnetic stimulation to pharmaceutical interventions and awareness-based techniques. Therefore, bioethics should also take a closer look at resilience and resilience research, which are today philosophically under-theorized. In this paper, we analyze different conceptualizations of resilience and argue that especially one-sided understandings of resilience which dismiss social and cultural contexts of personal resilience do pose social and ethical problems. On a social level such unbalanced views on resilience could hide and thereby stabilize structural social injustices, and on an individual level it might even lead to an aggravation of stress-related mental health problems by overexerting the individual. Furthermore, some forms of fostering resilience could be a latent form of human enhancement and trigger similar criticisms.

Patients participate in clinical trials for a variety of reasons, the first of which is often the prospect of direct health Benefit for themselves. Healthy volunteers, by definition, cannot expect such benefits. In resource-limited settings, healthy volunteers are most often poor people with low literacy levels who might not understand the Risks they may be taking and are in no position to refuse Financial incentives. For many of them, participation in clinical trials is a critical source of income. An added complication is that some participants covertly enrol in several studies simultaneously, in order to increase their income. This exposes the volunteers to medical risks, and also potentially biases study Data. Our recommendations are that specific efforts are made to ensure proper informed Consent of this Vulnerable population and that compulsory national databases be established to ensure that healthy volunteers do not participate simultaneously in several studies.

In contrast to other approaches, `modernity' in this article is not dealt with as a historical concept but as a normative-aesthetic term and as a mythical narrative in the sense of Nietzsche's `eternal recurrence of the same'. Paradoxically, there still exists a semantic shift between different historical concepts of modernity beginning in late antiquity and the Middle Ages up to the present confusions about `postmodernity'. However, the aesthetical bias of the discourse of modernity prevents any serious interpretation which is able to refer these semantic shifts directly to some clear and incontestable socio-structural facts and developments. In its contemporary sociological form this discourse overlaps on the contrary with some main trends in aesthetic theory and practice: the exchangeability between `old' and `new' and the permanent suspension of the boundaries between `art' and `life'. Consequently, aesthetics as well as sociology are describing modernity as a cultural system which is `playing' with its own fundamental differentiations between `in' and `out' or self-reference and other-reference

Plato’s Phaidon, as generally held, is set in Phlius (northern Argolis), shortly after the death of Socrates: the scarcely twenty-year-old Phaidon (see 89b2), on his way from Athens to his home town of Elis, is visiting the Pythagorean Echecrates and his companions. In this article I will show that the established place and time neglect some special dynamics of the start of the meeting (Section I) and a series of ethopoietic effects in the course of the dialogue (Section II). Moreover, relevant testimonies about Echecrates of Phlius and some adverbial references (especially 118a16 τότε) suggest that the dramatic time of the dialogue should be understood as set substantially later (Section III). Finally, general reflections on the naturalness of the whole setting (Section IV) seem to confirm that in the Platonic Phaidon, the already more mature Phaidon, when visited ‘years after’ (Wilamowitz) in Elis by the Pythagorean Echecrates, reports details of the memorable death of his former master.

Today’s social, economic, ecological and political state-of-affairs, the lack of confidence in business and political leaders and the associated rise of populist parties pose new and structurally different challenges to mankind. They are likely to be deepened in the course of the implementation of the Agenda 2030 for Sustainable Development. While all societal actors are called upon to reflect on their contribution to necessary reforms, business has a particularly important role to play. Competing with integrity today means much more than compliance with law and regulation. The article discusses the necessity of top manager’s reflection on values and coherent practical action and uses the World Ethos body of thought as a compass. It also draws attention to the complexity of such a values management and stresses the importance of ethical leadership.

In this brief essay, we will argue that modern neuroscience and Whitehead’s process thinking arrive at rather similar conclusions about the essence of human experiences. Important issues evolving from neuroscientific research, specifying the identity of human beings, are explained as resulting from the development and stepwise changes of highly dynamic neuronal networks. These conclusions appear to fit the physical concepts developed by Whitehead, who claims that the elucidation of immediate experience, proceeding from objectivity to subjectivity, is the sole justification of our thought. Both lines of thought assume that our bodily experience, emerging from the perception of various bodily organs, is the basis of our existence.