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    Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development
    with A. Mathur, P. Loskill, S. Hong, J. Lee, Marcus S. G., L. Dumont, B. R. Conklin, H. Willenbring, and K. E. Healy
    Drug discovery and development to date has relied on animal models, which are useful but are often expensive, slow, and fail to mimic human physiology. The discovery of human induced pluripotent stem cells has led to the emergence of a new paradigm of drug screening using human and disease-specific organ-like cultures in a dish. Although classical static culture systems are useful for initial screening and toxicity testing, they lack the organization of differentiated iPS cells into microphysiol…Read more
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    Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration
    with D. Klepach, J. F. Wenk, M. B. Ratcliffe, T. I. Zohdi, J. L. Navia, G. S. Kassab, E. Kuhl, and J. M. Guccione
    Cardiac growth and remodeling in the form of chamber dilation and wall thinning are typical hallmarks of infarct-induced heart failure. Over time, the infarct region stiffens, the remaining muscle takes over function, and the chamber weakens and dilates. Current therapies seek to attenuate these effects by removing the infarct region or by providing structural support to the ventricular wall. However, the underlying mechanisms of these therapies are unclear, and the results remain suboptimal. He…Read more