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    A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection
    with W. Deng, B. G. Gowen, L. Zhang, S. Lau, A. Iannello, J. Xu, T. L. Rovis, N. Xiong, and D. H. Raulet
    Immune cells, including natural killer cells, recognize transformed cells and eliminate them in a process termed immunosurveillance. It is thought that tumor cells evade immunosurveillance by shedding membrane ligands that bind to the NKG2D-activating receptor on NK cells and/or Tcells, and desensitize these cells. In contrast, we show that in mice, a shed form of MULT1, a high-affinity NKG2D ligand, causes NK cell activation and tumor rejection. Recombinant soluble MULT1 stimulated tumor reject…Read more
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    Recognition of tumors by the innate immune system and natural killer cells
    with Marcus A., B. G. Gowen, T. W. Thompson, A. Iannello, M. Ardolino, W. Deng, N. Shifrin, and D. H. Raulet
    In recent years, roles of the immune system in immune surveillance of cancer have been explored using a variety of approaches. The roles of the adaptive immune system have been a major emphasis, but increasing evidence supports a role for innate immune effector cells such as natural killer cells in tumor surveillance. Here, we discuss some of the evidence for roles in tumor surveillance of innate immune cells. In particular, we focus on NK cells and other immune cells that express germline-encod…Read more