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77Discovery by serendipity: A new context for an old Riddle (review)Foundations of Chemistry 11 (1): 33-42. 2008.In the last years there has been a great improvement in the development of computational methods for combinatorial chemistry applied to drug discovery. This approach to drug discovery is sometimes called a “rational way” to manage a well known phenomenon in chemistry: serendipity discoveries. Traditionally, serendipity discoveries are understood as accidental findings made when the discoverer is in quest for something else. This ‘traditional’ pattern of serendipity appears to be a good character…Read more
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52From the beginnings of the biochemistry as discipline, the dichotomy between in vivo- in vitro conditions has been in the center of their methodological discussions. With the growing influence of computer simulations - sometimes called "in silico" conditions-, a new methodological problem is added to biochemistry. However, "simulation" could be seen as a core concept that is in fact used in the in vivo - in vitro dichotomy. In this sense, in silico dimension could be considered as a natural exte…Read more
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22Computer simulations and experiments: in vivo–in vitro conditions in biochemistryFoundations of Chemistry 17 (1): 49-65. 2015.Scientific practices have been changed by the increasing use of computer simulations. A central question for philosophers is how to characterize computer simulations. In this paper, we address this question by analyzing simulations in biochemistry. We propose that simulations have been used in biochemistry long before computers arrived. Simulation can be described as a surrogate relationship between models. Moreover, a simulative aspect is implicit in the classical dichotomy between in vivo–in v…Read more
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5Spanish psychometric properties of the moral distress scale—revised: a study in healthcare professionals treating COVID-19 patientsBMC Medical Ethics 24 (1): 1-12. 2023.Background Moral distress appears when a healthcare professional is not able to carry out actions in accordance with their professional ethical standards. The Moral Distress Scale-Revised is the most widely used to assess levels of moral distress, but it is not validated in Spanish. The aim of the study is to validate the Spanish version of the Moral Distress Scale – utilised within a sample of Spanish healthcare professionals treating COVID–19 patients. Methods The original (english) and the po…Read more
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5Estrategias de modelización en Alan Turing: términos y conceptos de máquinaTópicos: Revista de Filosofía 58 135-155. 2019.In 1936, Alan Turing proposed the notion of an automated machine as a model of the computation performed by a human being while only being aided by mechanical resources. Still, it seems that much more can be said about Turing’s own conception of machines in the scope of his later work, both terminologically and conceptually. In this paper we present the terms he used that refer to machines and that according to our understanding are important to give an account of Turing’s concerns and the probl…Read more
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1Programas de investigación y estrategias metodológicas: cuestiones conceptuales e históricasPáginas de Filosofía 21 (24): 9-37. 2021.En los años veinte del siglo pasado se constituye lo que luego se llamó la escuela de Cambridge en bioquímica. Bajo el liderazgo de Frederick Gowland Hopkins este grupo tenía como objetivo primario la consolidación de la naciente bioquímica. Una característica particular de este grupo fue el intento explícito de vincular el trabajo científico con la discusión filosófica. Sin embargo, algunos historiadores como Nils Roll-Hansen han cuestionado en duros términos la manera en la cual estos científi…Read more
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1A Role for Cognitive Agents from a Kuhnian Point of View: A Comment to Juan Vicente MayoralIn Pablo Melogno, Hernán Miguel & Leandro Giri (eds.), Perspectives on Kuhn: Contemporary Approaches to the Philosophy of Thomas Kuhn, Springer. pp. 83-92. 2023.In his paper, Juan Vicente Mayoral presents various aspects of Kuhn’s thought from a historical perspective. Besides the interesting approach that Mayoral proposes for several problems, in this commentary I am going to address only the relevance of the individual in Kuhn. This point can be considered a secondary aspect of Mayoral work, but I think it will allow us to address at least some of Mayoral reading strategies. And even when Mayoral makes few references to the role of individuals, in tho…Read more
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Experimentación, materialidad y simulaciones computacionalesIn A. Torrano & A. Passos Videira (eds.), Representación en Ciencia y Arte, Editorial Brujas. pp. 73-82. 2003.
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Epistemología e historia de la ciencia: Selección de trabajos de las XX jornadas (edited book)Editorial Universidad Nacional de Cȯrdoba. 2010.
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Jorge Santayana y los acontecimientos de 1898Teorema: International Journal of Philosophy 21 (1-3). 2002.