• Background: In vivo, non-invasive optical coherence tomography permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies. Purpose: To evaluate the clinical capability of non-invasive in vivo OCT for diagnosing oral dysplasia and malignancy. Experimental Design: In 50 patients with oral lesions, conventional clinical examination was followed by OCT imaging, then standard biopsy and histopathology. Two blin…Read more
  • In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography
    with M. J. Hammer-Wilson, J. Zhang, Q. Wang, K. Osann, Z. Chen, H. Wigdor, J. Schwartz, and J. Epstein
    Purpose: To assess noninvasive optical coherence tomography and optical Doppler tomography for early detection and evaluation of chemotherapy-induced oral mucositis. Experimental Design: Cheek pouches of 10 Syrian golden hamsters were imaged using OCT/ODT during development of chemotherapy-induced mucositis. I.p. injections of 5-fluorouracil and mechanical irritation induced oral lesions. At 2, 4, 7, and 11 days, one hamster was sacrificed and processed for histopathology. OCT images were visual…Read more
  • Noninvasive imaging of oral premalignancy and malignancy
    with T. Krasieva, W. G. Jung, J. Zhang, Z. Chen, K. Osann, and B. Tromberg
    Early detection of cancer and its precursors remains the best way to ensure patient survival and quality of life. Our specific aim is to test a multimodality approach to noninvasive diagnostics of oral premalignancy and malignancy. In the hamster cheek pouch model, in vivo optical coherence tomography and optical Doppler tomography map epithelial, subepithelial, and vascular change throughout carcinogenesis. In vivo multiwavelength multiphoton and second-harmonic generated fluorescence technique…Read more