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    Pacap intraperitoneal treatment suppresses appetite and food intake via PAC1 receptor in mice by inhibiting ghrelin and increasing GLP-1 and leptin (review)
    with J. P. Vu, D. Goyal, L. Luong, S. Oh, J. Norris, W. Parsons, Pisegna Jr, and P. M. Germano
    © 2015 the American Physiological Society. Pituitary adenylate cyclase-activating peptide is expressed within the gastroenteric system, where it has profound physiological effects. PACAP was shown to regulate food intake and thermogenesis centrally; however, PACAP peripheral regulation of appetite and feeding behavior is unknown. Therefore, we studied PACAP’s effect on appetite and food intake control by analyzing feeding behavior and metabolic hormones in PAC1-deficient and age-matched wild-typ…Read more