• Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease
    with J. L. Haines, M. Smith, H. Northrup, R. J. M. Gardner, M. P. Short, K. Dumars, E. S. Roach, S. Steingold, S. Wall, S. H. Blanton, P. Flodman, D. J. Kwiatkowski, A. Jewell, J. L. Weber, A. D. Roses, and M. A. Pericak-Vance
    Tuberous sclerosis complex is an autosomal dominant disorder of unknown aetiology that affects numerous body systems including skin, brain and kidneys. Some TSC has been linked to chromosome 9, additional TSC genes on chromosomes 11 and 12 have been proposed, but the majority of TSC families remain unlinked. Using TSC families in which data had excluded linkage to chromosome 9, we failed to detect linkage with loci on chromosomes 11, 12 and others. One marker examined was D16S283, the closest lo…Read more