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The principle of sufficient reason can be taken as a guide to the progress of philosophical and scientific knowledge. Thus, we could establish a link between scientific disciplines and philosophy, which would result in a mutually enriching dialogue. However, it can be shown that the use of the principle of sufficient reason is not suitable for the philosophical and scientific research, so neither can be used to establish a dialogue. It is argued, therefore, that other principles must be deepened, e.g., causality, to establish a link between science and philosophy.

The Principle of Sufficient Reason: According to Alexander R. Pruss the Principle of Sufficient Reason is essential to solve two classical problems of philosophy: 1) the problem of infinite regress and 2) the non-emergence of entities ex nihilo. Furthermore, the use of the PSR would correspond to an Aristotelian-Thomistic explanation of the metaphysical structure of individuals. However, the argument developed by Pruss has some defects that ultimately lead to the conclusion that the PSR is superfluous.

The Mind of the Universe and Causality : In The Mind of the Universe Mariano Artigas builds a bridge connecting science and theology. One of the connections he establishes between the two areas of knowledge goes through the philosophy of nature, specifically through the study of causality; in fact, in The Mind of the Universe can be found ways to understand and to expose the Aristotelian-Thomistic doctrine of causality that allow, on the one hand, the connection between science and theology and, on the other hand, going deeper into the philosophical understanding of the natural world.