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    Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice (review)
    with T. T. Chang, T. Wei, R. M. Ransohoff, V. K. Kuchroo, and A. H. Sharpe
    Adoptive transfer experiments using C57BL/6 mice lacking B7-1 and B7-2 as recipients of wt encephalitogenic T cells demonstrate a key role for B7 costimulation during the effector phase of experimental autoimmune encephalomyelitis. Following transfer of encephalitogenic T cells, B7-1/B7-2-deficient recipients develop a transient and mild disease as compared to wt recipients. To understand the mechanism by which B7-1/B7-2 may influence the effector phase of EAE, we analyzed T cells, pro-inflammat…Read more
  •  2
    Genetic background determines the requirement for B7 costimulation in induction of autoimmunity
    with C. Jabs, B. Greve, T. T. Chang, A. H. Sharpe, and V. K. Kuchroo
    B7 costimulatory molecules play an important role in inducing autoimmunity, tumor immunity, and transplant rejection, and therapeutic manipulation of B7 is being investigated in human diseases. To determine whether B7 costimulation is essential for inducing autoimmunity on different genetic backgrounds, we backcrossed B7.1/B7.2 deficient ) mice on to the C57BL/6 and SJL backgrounds and induced experimental autoimmune encephalomyelitis in these mice. B7.1/B7.2 mice on the B6 background were resis…Read more