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7Background: The purpose of this study was to investigate the capabilities of a novel optical wide-field imaging technology known as spatial frequency domain imaging to quantitatively assess reconstructive tissue status. Methods: Twenty-two cutaneous pedicle flaps were created on 11 rats based on the inferior epigastric vessels. After baseline measurement, all flaps underwent vascular ischemia, induced by clamping the supporting vessels for 2 hours ; normal saline was injected into the control fl…Read more
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4© 2014 American Heart Association, Inc.Background: Early afterdepolarizations are triggers of cardiac arrhythmia driven by L-type Ca2+ current reactivation or sarcoplasmic reticulum Ca2+ release and Na+/Ca2+ exchange. In large mammals the positive action potential plateau promotes ICaL reactivation, and the current paradigm holds that cardiac EAD dynamics are dominated by interaction between ICaL and the repolarizing K+ currents. However, EADs are also frequent in the rapidly repolarizing mouse …Read more
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3© 2015 American Neurological Association. Objective Mutations in the gene encoding the prion protein are responsible for approximately 10 to 15% of cases of prion disease in humans, including Creutzfeldt-Jakob disease. Here, we report on the discovery of a previously unreported C-terminal PrP mutation in a CJD patient exhibiting a disease similar to the rare VV1 subtype of sporadic CJD and investigate the role of this mutation in prion replication and transmission. Methods We generated transgeni…Read more
Aalborg, North Jutland Region, Denmark