•  55
    The role of ATF‐2 in oncogenesis
    with Stella Logotheti, Dimitris Mikas, Athina Giarika, Vassilis Gorgoulis, and Vassilis Zoumpourlis
    Bioessays 30 (4): 314-327. 2008.
    Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for AT…Read more
  •  20
    Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue‐specific intervention possible?
    with John A. Copland, Melinda Sheffield-Moore, Nina Koldzic-Zivanovic, Sean Gentry, George Lamprou, Fotini Tzortzatou-Stathopoulou, Vassilis Zoumpourlis, and Randall J. Urban
    Bioessays 31 (6): 629-641. 2009.
    Sex steroids, through their receptors, have potent effects on the signal pathways involved in osteogenic or myogenic differentiation. However, a considerable segment of those signal pathways has a prominent role in epithelial neoplastic transformation. The capability to intervene locally has focused on specific ligands for the receptors. Nevertheless, many signals are mapped to interactions of steroid receptor motifs with heterologous regulatory proteins. Some of those proteins interact with the…Read more