•  4
    Large conformational changes of insertion 3 in human glycyl-tRNA synthetase during catalysis
    with X. Qin, L. Chen, Q. Jia, Y. Zhang, Z. Zhang, D. Lei, G. Ren, Z. Zhou, Z. Wang, Q. Li, and W. Xie
    © 2016, American Society for Biochemistry and Molecular Biology Inc. All rights reserved.Glycyl-tRNA synthetase is the enzyme that covalently links glycine to cognate tRNA for translation. It is of great research interest because of its nonconserved quaternary structures, unique species-specific aminoacylation properties, and noncanonical functions in neurological diseases, but none of these is fully understood. We report two crystal structures of human GlyRS variants, in the free form and in co…Read more
  •  4
    Detection of Trypanosoma cruzi DNA in blood by PCR is associated with Chagas cardiomyopathy and disease severity
    with Ece Sabino, Alp Ribeiro, Lee Th, Cl Oliveira, Abf Carneiro-Proietti, Ap Antunes, Mm Menezes, Bma Ianni, Vmcc Salemi, L. Nastari, Fs Fernandes, V. Sachdev, Dm Carrick, Dj Wright, Tt Gonçalez, El Murphy, Bs Custer, and Mp Busch
    © 2015 The Authors. Background: The significance of detection of Trypanosoma cruzi DNA in blood of antibody-positive patients for risk of development of Chagas heart disease is not well established. The objective of this study was to compare detection of T. cruzi DNA with known clinical and laboratory markers of Chagas cardiomyopathy severity. Methods: This is a case-control study nested within a retrospective cohort developed in Brazil to understand the natural history of Chagas disease. The st…Read more
  •  3
    Neural anomaly and reorganization in speakers who stutter: A short-term intervention study
    with C. Lu, C. Chen, D. Peng, W. You, X. Zhang, G. Ding, Q. Yan, and P. Howell
    Objectives: The aim of the current study was to differentiate between neural activity that represents neural anomalies that are responsible for persistent developmental stuttering from the activity that is a result of compensating for stuttering. This was done by investigating alterations to the intrinsic functional architecture of speech-language processes of patients with PDS before and after a short-term intervention. Methods: The resting-state functional connectivity and cortical thickness w…Read more