-
377TGF-beta signaling proteins and the Protein OntologyBMC Bioinformatics 10 (Suppl 5). 2009.The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the…Read more
-
377Survey-based naming conventions for use in OBO Foundry ontology developmentBMC Bioinformatics 10 (1): 125. 2009.A wide variety of ontologies relevant to the biological and medical domains are available through the OBO Foundry portal, and their number is growing rapidly. Integration of these ontologies, while requiring considerable effort, is extremely desirable. However, heterogeneities in format and style pose serious obstacles to such integration. In particular, inconsistencies in naming conventions can impair the readability and navigability of ontology class hierarchies, and hinder their alignment and…Read more
-
376Persistence and Ontological PluralismIn Christian Kanzian (ed.), Persistence, Ontos. pp. 33-48. 2007.We aim to provide the ontological grounds for an adequate account of persistence. We defend a perspectivalist, or moderate pluralist, position, according to which some aspects of reality can be accounted for in ontological terms only via partial and mutually complementary ontologies, each one of which captures some relevant aspect of reality. Our thesis here is that this is precisely the sort of ontological account that is needed for the understanding of persistence, specifically an account invo…Read more
-
375The Environment Ontology: Contextualising biological and biomedical entitiesJournal of Biomedical Semantics 4 (43): 1-9. 2013.As biological and biomedical research increasingly reference the environmental context of the biological entities under study, the need for formalisation and standardisation of environment descriptors is growing. The Environment Ontology (ENVO) is a community-led, open project which seeks to provide an ontology for specifying a wide range of environments relevant to multiple life science disciplines and, through an open participation model, to accommodate the terminological requirements of all t…Read more
-
375The Benefits of Realism: A Realist Logic with ApplicationsIn Katherine Munn & Barry Smith (eds.), Applied Ontology: An Introduction, Ontos. pp. 109-124. 2008.We propose a formalization of a realist ontology using first order logic with identity and allowing quantification over terms representing both individuals and universals. In addition to identity, the ontology includes also relational predicates such as subtype, instantiation, parthood, location, and inherence. Inspired in part by Davidson’s treatment of events, the ontology includes also various relations linking events to their participants and to the times at which they occur.
-
371Roman Ingarden: Ontological Foundations for Literary TheoryIn John Odmark (ed.), Language, Literature and Meaning I: Problems of Literary Theory, Benjamins. pp. 373-390. 1979.The paper seeks to apply the work of the Polish phenomenologist Roman Ingarden to certain problems in literary theory; contrasts the notions of ontological and epistemological incompleteness of the represented objects of a literary work and considers the question of the nature of such objects. The paper concludes by analyzing some of the degrees of freedom possessed by the readings of literary work in relation to the work itself.
-
371Bodily Systems and the Modular Structure of the Human BodyArtificial Intelligence in Medicine (Lecture Notes on Artificial Intelligence 2780) 9 86-90. 2003.Medical science conceives the human body as a system comprised of many subsystems at a variety of levels. At the highest level are bodily systems proper, such as the endocrine system, which are central to our understanding of human anatomy, and play a key role in diagnosis and in dynamic modeling as well as in medical pedagogy and computer visualization. But there is no explicit definition of what a bodily system is; such informality is acceptable in documentation created for human beings, but f…Read more
-
370Ontology-assisted database integration to support natural language processing and biomedical data-miningJournal of Integrative Bioinformatics. Repr. In: Yearbook of Bioinformatics , 39–48 1 1-10. 2004.Successful biomedical data mining and information extraction require a complete picture of biological phenomena such as genes, biological processes, and diseases; as these exist on different levels of granularity. To realize this goal, several freely available heterogeneous databases as well as proprietary structured datasets have to be integrated into a single global customizable scheme. We will present a tool to integrate different biological data sources by mapping them to a proprietary biome…Read more
-
369Adapting Clinical Ontologies in Real-World EnvironmentsJournal of Universal Computer Science 14 (22): 3767-3780. 2008.The desideratum of semantic interoperability has been intensively discussed in medical informatics circles in recent years. Originally, experts assumed that this issue could be sufficiently addressed by insisting simply on the application of shared clinical terminologies or clinical information models. However, the use of the term ‘ontology’ has been steadily increasing more recently. We discuss criteria for distinguishing clinical ontologies from clinical terminologies and information models. T…Read more
-
369Values in Contexts: An Ontological TheoryIn G. John M. Abbarno (ed.), Inherent and Instrumental Values: Excursions in Value Inquiry, University Press of America. pp. 17-29. 2014.Values exist not in isolation, but in complex wholes. Values are what they are because of the complex wholes in which they are situated. To do justice to this thesis will require a holistic ontology, a theory according to which many types of entities exist only as inseparable parts or moments of wider contexts or environments. An ontological theory of environments -- with roots in Gestalt psychology and the ecological psychology of J. J. Gibson and Roger Barker, and which is related also to the …Read more
-
369Quality Control for Terms and Definitions in Ontologies and TaxonomiesBMC Bioinformatics 7 (212): 1-12. 2006.Background: Ontologies and taxonomies are among the most important computational resources for molecular biology and bioinformatics. A series of recent papers has shown that the Gene Ontology (GO), the most prominent taxonomic resource in these fields, is marked by flaws of certain characteristic types, which flow from a failure to address basic ontological principles. As yet, no methods have been proposed which would allow ontology curators to pinpoint flawed terms or definitions in ontologies …Read more
-
369The Plant Ontology facilitates comparisons of plant development stages across speciesFrontiers in Plant Science 10. 2019.The Plant Ontology (PO) is a community resource consisting of standardized terms, definitions, and logical relations describing plant structures and development stages, augmented by a large database of annotations from genomic and phenomic studies. This paper describes the structure of the ontology and the design principles we used in constructing PO terms for plant development stages. It also provides details of the methodology and rationale behind our revision and expansion of the PO to cover …Read more
-
366The Industrial Ontologies Foundry (IOF) Core OntologyFOMI 2022: 12th International Workshop on Formal Ontologies Meet Industry, September 12-15, 2022, Tarbes, France. 2022.The Industrial Ontologies Foundry (IOF) was formed to create a suite of interoperable ontologies. Ontologies that would serve as a foundation for data and information interoperability in all areas of manufacturing. To ensure that each ontology is developed in a structured and mutually coherent manner, the IOF has committed to the tiered architecture of ontology building based on the Basic Formal Ontology (BFO) as top level. One of the critical elements of a successful tiered architecture build i…Read more
-
364Wittgenstein und das ethische GesetzIn Dieter Birnbacher & Armin Burkhardt (eds.), Sprachspiel und Methode: zum Stand der Wittgenstein-Diskussion, Walter De Gruyter. pp. 191-211. 1985.Der vorliegende Aufsatz stellt den Versuch dar, die normative Seite von Wittgensteins Frühwerk herauszuarbeiten und dabei an seinem Ansatz insofern Kritik zu üben, als gezeigt wird, wie sehr dessen Implikationen mit unseren üblichen ethischen Vorstellungen in Konflikt stehen. Die Arbeit hat aber auch einen etwas wohlwollenderen Aspekt: Sie versucht zu zeigen, wie Wittgensteins scheinbar widersinnige Ansichten so formuliert werden können, daß sie zumindest begreifbar erscheinen. Zu diesem Zweck b…Read more
-
362Biomedical ontology alignment: An approach based on representation learningJournal of Biomedical Semantics 9 (21). 2018.While representation learning techniques have shown great promise in application to a number of different NLP tasks, they have had little impact on the problem of ontology matching. Unlike past work that has focused on feature engineering, we present a novel representation learning approach that is tailored to the ontology matching task. Our approach is based on embedding ontological terms in a high-dimensional Euclidean space. This embedding is derived on the basis of a novel phrase retrofittin…Read more
-
362Kasimir Twardowski: An Essay on the Borderlines of Psychology, Ontology and LogicIn K. Szaniawski (ed.), The Vienna Circle and the Philosophy of the Lvov-Warsaw School, Kluwer Academic Publishers. pp. 313--375. 1988.The influence of Kasimir Twardowski on modern Polish philosophy is all-pervasive. As is well known, almost all important 20th century Polish philosophers went through the hard training of his courses in Lvov. Twardowski instilled in his students an enduring concern for clarity and rigour. He taught them to regard philosophy as a collaborative effort, a matter of disciplined discussion and argument. And he encouraged them to work together with scientists from other disciplines — above all with ps…Read more
-
359Ontological Support for Living Plan Specification, Execution and EvaluationIn Erik Thomsen, Fred Read, William Duncan, Tatiana Malyuta & Barry Smith (eds.), Semantic Technology in Intelligence, Defense and Security (STIDS), CEUR vol. 1304, . pp. 10-17. 2014.Maintaining systems of military plans is critical for military effectiveness, but is also challenging. Plans will become obsolete as the world diverges from the assumptions on which they rest. If too many ad hoc changes are made to intermeshed plans, the ensemble may no longer lead to well-synchronized and coordinated operations, resulting in the system of plans becoming itself incoherent. We describe in what follows an Adaptive Planning process that we are developing on behalf of the Air Force …Read more
-
358On CredentialsJournal of Social Ontology 6 (1): 47-67. 2020.Credentials play an important role in all modern societies, but the analysis of their nature and function has thus far been neglected by social philosophers. We present a view according to which the function of credentials is certify the identity and the institutional status (including the rights) of individuals. More importantly, credentials enable rights-holders to exercise their rights, so that for a particular right to be exercisable the right-holder should possess, carry and sometimes show …Read more
-
357This paper presents the Obstetric and Neonatal Ontology (OntONeo). This ontology has been created to provide a consensus representation of salient electronic health record (EHR) data and to serve interoperability of the associated data and information systems. More generally, it will serve interoperability of clinical and translational data, for example deriving from genomics disciplines and from clinical trials. Interoperability of EHR data is important to ensuring continuity of care during the…Read more
-
356La géométrie cognitive de la guerreIn Smith Barry (ed.), Les Nationalismes, Puf. pp. 199--226. 2002.Why does ‘ethnic cleansing’ occur? Why does the rise of nationalist feeling in Europe and of Black separatist movements in the United States often go hand in hand with an upsurge of anti-Semitism? Why do some mixings of distinct religious and ethnic groups succeed, where others (for example in Northern Ireland, or in Bosnia) fail so catastrophically? Why do phrases like ‘balkanisation’, ‘dismemberment’, ‘mutilation’, ‘violation of the motherland’ occur so often in warmongering rhetoric? All of t…Read more
-
355Les objects sociauxPhilosophique 26 (2). 2002.One reason for the renewed interest in Austrian philosophy, and especially in the work of Brentano and his followers, turns on the fact that analytic philosophers have become once again interested in the traditional problems of metaphysics. It was Brentano, Husserl, and the philosophers and psychologists whom they influenced, who drew attention to the thorny problem of intentionality, the problem of giving an account of the relation between acts and objects or, more generally, between the psycho…Read more
-
355基于基本形式化本体的本体构建People's Medical Publishing House. 2020.In the era of “big data,” science is increasingly information driven, and the potential for computers to store, manage, and integrate massive amounts of data has given rise to such new disciplinary fields as biomedical informatics. Applied ontology offers a strategy for the organization of scientific information in computer-tractable form, drawing on concepts not only from computer and information science but also from linguistics, logic, and philosophy. This book provides an introduction to the…Read more
-
355Ontology-driven multicriteria decision support for victim evacuationInternational Journal of Information Technology and Decision Making. 2021.Abstract In light of the complexity of unfolding disasters, the diversity of rapidly evolving events, the enormous amount of generated information, and the huge pool of casualties, emergency responders (ERs) may be overwhelmed and in consequence poor decisions may be made. In fact, the possibility of transporting the wounded victims to one of several hospitals and the dynamic changes in healthcare resource availability make the decision process more complex. To tackle this problem, we propose a …Read more
-
353The HL7 approach to semantic interoperabilityIn Proceedings of the 2nd International Conference on Biomedical Ontology, Ceur, Vol. 833. pp. 139-146. 2011.Health Level 7 (HL7) is an international standards development organisation in the domain of healthcare information technology. Initially the mission of HL7 was to enable data exchange via the creation of syntactic standards which supported point-to-point messaging. Currently HL7 sees its mission as one of creating standards for semantic interoperability in healthcare IT on the basis of its flagship “version 3” (v3). Unfortunately, v3 has been plagued by quality and consistency issues, and it ha…Read more
-
353Functional anatomy: A taxonomic proposalActa Biotheoretica 53 (3): 153-166. 2005.It is argued that medical science requires a classificatory system that (a) puts functions in the taxonomic center and (b) does justice ontologically to the difference between the processes which are the realizations of functions and the objects which are their bearers. We propose formulae for constructing such a system and describe some of its benefits. The arguments are general enough to be of interest to all the life sciences.
-
353Clonal complexes in biomedical ontologiesIn Barry Smith (ed.), ICBO 2009: Proceedings of the First International Conference on Biomedical Ontology, Ncor. pp. 168. 2009.An accurate classification of bacteria is essential for the proper identification of patient infections and subsequent treatment decisions. Multi-Locus Sequence Typing (MLST) is a genetic technique for bacterial classification. MLST classifications are used to cluster bacteria into clonal complexes. Importantly, clonal complexes can serve as a biological species concept for bacteria, facilitating an otherwise difficult taxonomic classification. In this paper, we argue for the inclusion of terms …Read more
-
352Bioinformatics advances in saliva diagnosticsInternational Journal of Oral Science 4 (2): 85--87. 2012.There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create a data management system and web resource constructed to support human salivaomics research. To maximize the utility of the SKB for retrieval, integration and analysis of data, we have developed the Saliva Ontology and SDxMart. This article reviews the in…Read more
-
352Fiat objectsIn Nicola Guarino, Laure Vieu & Simone Pribbenow (eds.), Parts and Wholes: Conceptual Part-Whole Relations and Formal Mereology, 11th European Conference on Artificial Intelligence, Amsterdam, 8 August 1994, Amsterdam:, European Coordinating Committee For Artificial Intelligence. pp. 14-22. 1994.Human cognitive acts are directed towards entities of a wide range of different types. What follows is a new proposal for bringing order into this typological clutter. A categorial scheme for the objects of human cognition should be (1) critical and realistic. Cognitive subjects are liable to error, even to systematic error of the sort that is manifested by believers in the Pantheon of Olympian gods. Thus not all putative object-directed acts should be recognized as having objects of their own. …Read more
-
351On Creativity and the Philosophy of the Supranational StateIn Tamás Demeter (ed.), Essays on Wittgenstein and Austrian Philosophy: In Honour of J.C. Nyíri, Brill. pp. 25-39. 2004.Building on the writings of Wittgenstein on rule-following and deviance, Kristóf Nyíri advanced a theory of creativity as consisting in a fusion of conflicting rules or disciplines. Only such fusion can produce something that is both intrinsically new and yet capable of being apprehended by and passed on to a wider community. Creativity, on this view, involves not the breaking of rules, or the deliberate cultivation of deviant social habits, but rather the acceptance of enriched systems of rules…Read more
-
351A terminological and ontological analysis of the NCI thesaurusMethods of Information in Medicine 44 (4): 498-507. 2005.We performed a qualitative analysis of the Thesaurus in order to assess its conformity with principles of good practice in terminology and ontology design. We used both the on-line browsable version of the Thesaurus and its OWL-representation (version 04.08b, released on August 2, 2004), measuring each in light of the requirements put forward in relevant ISO terminology standards and in light of ontological principles advanced in the recent literature. Version 04.08b of the NCI Thesaurus suffers…Read more
Barry Smith
University at Buffalo
National Center for Ontological Research
-
University at BuffaloDepartment of Philosophy
Biomedical Informatics
Neurology
Computer Science and EngineeringDistinguished Professor, Julian Park Chair -
National Center for Ontological ResearchAdministrator
-
APA Eastern Division
Buffalo, New York, United States of America
Areas of Specialization
Metaphysics |
Ontology |
Philosophy of Artificial Intelligence |
Philosophy of Biology |