David S. Oderberg

Common sense tells us that biological systems are goal-directed, and yet the concept remains philosophically problematic. We propose a novel characterization of goal-directed activities as a basis for hypothesizing about and investigating explanatory mechanisms. We focus on survival goals such as providing adequate nutrition to body tissues, highlighting two key features—normativity and action. These are closely linked inasmuch as goal-directed actions must meet normative requirements such as that they occur when required and not at other times. We illustrate how goal-directed actions are initiated and terminated not by environmental features and goals themselves, but by markers for them. For example, timely blood clotting is the essential response to injury, but platelet activation, required for clotting, is initiated not by the injury itself but by a short sequence of amino acids (GPO) that provides a reliable marker for it. We then make the case that the operation of markers is a prerequisite for common biological phenomena such as mistake-proneness and mimicry. We go on to identify properties of markers in general, including those that are genetically determined and those that can be acquired through associative learning. Both provide the basis for matching actions to changing environments and hence adaptive goal-directedness. We describe how goal-directed activities such as bird nest construction and birdsong learning, completed in anticipation of actions in the environment, have to be evaluated and practiced against a standard of correctness. This characterization of goal-directedness is sufficiently detailed to provide a basis for the scientific study of mechanisms.

This paper tests the following hypothesis: that the prime matter of classical Aristotelian-Scholastic metaphysics is numerically identical to energy. Is P=E? After outlining the classical Aristotelian concept of prime matter, I provide the master argument for it based on the phenomenon of substantial change. I then outline what we know about energy as a scientific concept, including its role and application in some key fields. Next, I consider the arguments in favour of prime matter being identical to energy, followed by the arguments against. The method used is that of ontological profile comparison: does the profile of prime matter match, in key features, that of energy? An affirmative answer, that P=E, would be a momentous discovery: it would show that one of the most neglected and derided ideas of pre-modern metaphysics – a contributor to its downfall in the wake of the Scientific Revolution – was right all along. From a negative answer we would still learn much about the interaction of science and metaphysics. It turns out, however, given what we currently know, that the answer is not quite as simple as one might hope.

The making of mistakes by organisms and other living systems is a theoretically and empirically unifying feature of biological investigation. Mistake theory is a rigorous and experimentally productive way of understanding this widespread phenomenon. It does, however, run up against the long-standing “functions” debate in philosophy of biology. Against the objection that mistakes are just a kind of malfunction, and that without a position on functions there can be no theory of mistakes, we reply that this is to misunderstand the theory. In this paper we set out the basic concepts of mistake theory and then argue that mistakes are a distinctive phenomenon in their own right, not just a kind of malfunction. Moreover, the functions debate is, to a large degree, independent of the concept of biological mistakes we outline. In particular, although the popular selected effects theory may retain its place within a more pluralistic conception of biological function, there is also need for a more forward-looking approach, where a robust concept of normativity can be an important driver of future experimental work.

The active/passive distinction, once a hallmark of classical metaphysics, has largely been discarded from contemporary thought. The revival of powers theory has not seen an equally vigorous rehabilitation of the real distinction between active and passive powers. I begin an analysis and vindication with a critique of E.J. Lowe's discussion. I then argue that the active/passive problem is a metaphysical one, not a logical or logico‐linguistic one, and so logic is impotent to solve it. Following this is a discussion of the rights and wrongs of Aristotle's and Aquinas's (identical) defence of the distinction. We will see that one main part of their analysis is a bright red herring while the other part contains the solution to the problem. I then state and clarify the key Scholastic principle concerning action and passion, which I call the Fundamental Thesis – one that will appear scandalous to contemporary ears, yet from which we can derive the tools needed to understand action and passion in the right way. I end with a definition of what I call the Minimal Metaphysical Agent, where the formulation is to be understood as an epistemic criterion for identifying agent and patient in a given causal interaction.

Until quite recently, mind-body dualism has been regarded with deep suspicion by both philosophers and scientists. This has largely been due to the widespread identification of dualism in general with one particular version of it: the interactionist substance dualism of Réné Descartes. This traditional form of dualism has, ever since its first formulation in the seventeenth century, attracted numerous philosophical objections and is now almost universally rejected in scientific circles as empirically inadequate. During the last few years, however, renewed attention has begun to be paid to the dualistic point of view, as a result of increasing discontent with the prevailing materialism and reductionism of contemporary scientific and philosophical thought. Awareness has grown that dualism need not be restricted to its traditional form and that other varieties of dualism are not subject to the difficulties commonly raised against Descartes' own version of it. Interest in these alternative versions of dualism is growing fast today, because it seems that they are capable of capturing deep-seated philosophical intuitions, while also being fully consistent with the methodological assumptions and empirical findings of modern scientific work on the human mind and brain. The object of this book is to provide philosophers, scientists, their students, and the wider general public with an up-to-date overview of current developments in dualistic conceptions of the mind in contemporary philosophy and science.

What follows axe the provisional conclusions reached in my thoughts about a frequently encountered, established argument for perceptual relativism. Rather than attempting the misleading task of dcfming in a sentence this doctrine - for it is so widely espoused by philosophers and Iaymcn alike that it deserves to bc called a doctrine — I shall instead elucidate it by thc common argu— ment for it that I wish to deal with, which Ishall call thc argument from differing perceptual apparatus, or ADP. Most people, myself included, encounter ADP in popular form, with the opening gambit: "Supposc a fly flew into the room objccts would appear to it totally different from the way they appear to us . . . "; or else: "Saiicnce is a function of 0nc’s environment — insects perceive sounds and colour-shades we would never pcrccivc, because they nccd this to suivivc." Generally, differences in environment and therefore in salicncc, manifest themselves in different or more or less finely-tuned sense organs. Some animals have sense organs quite different in type or rcccptivity from the traditional human "fivc SBl’1S6S”. (Other senses, such as the kinesthctic sense have, of course, been determined and added to thc traditional fivc.) The premise that can be distilled from these points is the basic empirical premise 0f ADP: different species have different perceptual apparatus, with the consequence that different classes of..

This book is a systematic investigation into the metaphysical foundations of identity over time. The author elaborates and evaluates the most common theory about the persistence of objects through time and change, namely the classical theory of spatio-temporal continuity. He shows how the theory requires an ontology of temporal parts, according to which objects are made up of temporally extended segments or stages. This ontology is criticized as unwarranted by modern space-time physics, and as internally incoherent. The author argues that identity over time should be seen as a primitive or unanalysable phenomenon, and that the so-called puzzle cases and paradoxes of identity can be dealt with without recourse to such an ontology.

Whereas Mereological Essentialism is the thesis that the parts of an object are essential to it, Reverse Mereological Essentialism is the thesis that the whole is essential to its parts. Specifically—since RME is an Aristotelian doctrine—it is a claim not about objects in general but about substances. Here I set out and explain RME as it should be understood from the perspective of the Aristotelian-Scholastic tradition, as well as proposing a kind of master argument for believing it. A number of objections (many of which have been raised by Kathrin Koslicki or Robert Koons) are then considered, the replies to which help further to clarify and motivate RME. The final section considers some important questions concerning parts and matter in light of Ross Inman’s recent defence of RME under the guise of what he calls Substantial Priority. Considering these questions further illustrates right and wrong ways of understanding RME. Overall, the case for Reverse Mereological Essentialism is strong albeit with a number of difficulties that need to be resolved through further investigation.

Organisms and other biological entities are mistake-prone: they get things wrong. The entities of pure physics, such as atoms and inorganic molecules, do not make mistakes: they do what they do according to physical law, with no room for error except on the part of the physicist or their theory. We set out a novel framework for understanding biology and its demarcation from physics – that of mistake-making. We distinguish biological mistakes from mere failures. We then propose a rigorous definition of mistakes that, although invoking the concept of function, is compatible with various views about what functions are. The definition of mistake-making is agential, since mistakes do not just happen ¬– at least in the sense analysed here – but are made. This requires, then, a notion of biological agency which we set out as a definition of the Minimal Biological Agent. The paper then considers a series of objections to the theory presented here, along with our replies. Two key features of our theory of mistakes are, first, that it is a supplement to, not a replacement for, existing general frameworks within which biology is understood and practised. Secondly, it is designed to be experimentally productive. Hence we end with a series of case studies where mistake theory can be shown to be useful in the potential generation of research questions and novel hypotheses of interest to the working biologist.

This paper tests the following hypothesis: that the prime matter of classical Aristotelian-Scholastic metaphysics is numerically identical to energy. Is P=E? After outlining the classical Aristotelian concept of prime matter, I provide the master argument for it based on the phenomenon of substantial change. I then outline what we know about energy as a scientific concept, including its role and application in some key fields. Next, I consider the arguments in favour of prime matter being identical to energy, followed by the arguments against. The method used is that of ontological profile comparison: does the profile of prime matter match, in key features, that of energy? An affirmative answer, that P=E, would be a momentous discovery: it would show that one of the most neglected and derided ideas of pre-modern metaphysics – a contributor to its downfall in the wake of the Scientific Revolution – was right all along. From a negative answer we would still learn much about the interaction of science and metaphysics. It turns out, however, given what we currently know, that the answer is not quite as simple as one might hope.

It is a matter of contention whether or not a general explanatory framework for the biological sciences would be of scientific value, or whether it is even achievable. In this paper we suggest that both are the case, and we outline proposals for a framework capable of generating new scientific questions. Starting with one clear characteristic of biological systems – that they all have the potential to make mistakes - we aim to describe the nature of this potential and the common processes that lie behind it. Given that under most circumstances biological systems function effectively, an examination of different kinds of mistake-making provides pointers to mechanisms that must exist to make failure uncommon. This in turn informs a framework for systematic enquiry, which in this paper we apply to the haemostatic system, but which we believe could be applied to any system across biology.

This paper defends partiality as an inherent, essential part of ethical decision-making. First, the concept of charity as a kind of universal benevolence is spelled out, drawing on key ideas from classical religious thinking. I then argue that any justification of partiality must appeal to the good first, rather than rights. There follows a justification of partiality via an argument from the idea of control over the good. The next section seeks to harmonize partialistic preference with universal charity, explaining the concept of love of neighbour. There follows an outline of the key principles required for setting out an order of charity based on different kinds of special relationship. While not all of this theistically driven approach to the order of charity translates easily into secular moral thought, enough does to suggest that the view defended is at the least worthy of consideration and not to be dismissed lightly. At best, it has much in it that is commendable to secular common sense.

We live in a liberal, pluralistic, largely secular society where, in theory, there is fundamental protection for freedom of conscience generally and freedom of religion in particular. There is, however, both in statute and common law, increasing pressure on religious believers and conscientious objectors (outside wartime) to act in ways that violate their sincere, deeply held beliefs. This is particularly so in health care, where conscientious objection is coming under extreme pressure. I argue that freedom of religion and conscience need to be put on a sounder footing both legislatively and by the courts, particularly in health care. I examine a number of important legal cases in the UK and US, where freedom of religion and conscience have come into conflict with government mandates or equality and anti-discrimination law. In these and other cases we find one of two results: either the conscientious objector loses out against competing rights, or the conscientious objector succeeds, but due to what I consider unsound judicial reasoning. In particular, cases involving cooperation in what the objector considers morally impermissible according to their beliefs have been wrongly understood by some American courts. I argue that a reasonable theory of cooperation incorporated into judicial thinking would enable more acceptable results that gave sufficient protection to conscientious objectors without risking a judicial backlash against objectors who wanted to take their freedoms too far. I also venture into broader, more controversial waters concerning what I call freedom of dissociation – the fundamental right to withdraw from associating with people, groups, and activities. It is no more than the converse of freedom of association, which all free societies recognise as a basic right. How far should freedom of dissociation go? What might society be like if freedom of dissociation were given more protection in law than it currently has? It would certainly give freedom of religion and conscience a substantial foundation, but it could also lead to discriminatory behaviour to which many people would object. I explore some of these issues, before going back to the narrower area of freedom of conscience and religion in health care, making some proposals about how the law could strengthen these basic pillars of a liberal, free society.

According to divine premotionism, God does not merely create and sustain the universe. He also moves all secondary causes to action as instruments without undermining their intrinsic causal efficacy. I explain and uphold the premotionist theory, which is the theory of St Thomas Aquinas and his most prominent exponents. I defend the premotionist interpretation of Aquinas in some textual detail, with particular reference to Suarez and to a recent paper by Louis Mancha. Critics, including Molinists and Suarezians, raise various objections to the view that premotion is compatible with genuine secondary causation. I rebut a number of these objections, in the course of which I respond to the central challenge that premotionism destroys free will. I also offer a number of positive reasons for embracing the premotionist theory.

The Dead Donor Rule holds that removing organs from a living human being without their consent is wrongful killing. The rule still prevails in most countries, and I assume it without argument in order to pose the question: is it possible to have a metaphysically correct, clinically relevant analysis of human death that makes organ donation possible? I argue that the two dominant criteria of death, brain death and circulatory death, are both empirically and metaphysically inadequate as definitions of human death, and therefore of no epistemic value in themselves. I first set out a neo-Aristotelian theory of death as separation of soul (understood as organising principle) and body, which is then fleshed out as loss of organismic integrity. The brain and circulatory criteria are shown to have severe weaknesses as physiological manifestations of loss of integrity. Given the mismatch between what death is metaphysically speaking, and the dominant criteria accepted by clinicians and philosophers, it turns out that only actual bodily decomposition is a sure sign of death. In this I differ from Alan Shewmon, whose important work I discuss in detail.

Tyron Goldschmidt has recently published a non-paper in which he claims to demonstrate the causal power of absences. His non-paper is, precisely, an empty page. The non-paper is ingenious and at first ‘glance’ the ‘reader’ might think that the absence of words on the page does prove that negative beings can literally cause states such as surprise or disappointment. Closer analysis, however, shows that Goldschmidt’s clever non-paper not only lacks words but also lacks causal power. Serious metaphysical problems pile up if we suppose otherwise.

_Real Essentialism_ presents a comprehensive defence of neo-Aristotelian essentialism. Do objects have essences? Must they be the kinds of things they are in spite of the changes they undergo? Can we know what things are really like – can we define and classify reality? Many, if not most, philosophers doubt this, influenced by centuries of empiricism, and by the anti-essentialism of Wittgenstein, Quine, Popper, and other thinkers. _Real Essentialism_ reinvigorates the tradition of realist, essentialist metaphysics, defending the reality and knowability of essence, the possibility of objective, immutable definition, and its relevance to contemporary scientific and metaphysical issues such as whether essence transcends physics and chemistry, the essence of life, the nature of biological species, and the nature of the person.