X. Wang

BackgroundLittle previous research has been conducted outside of major cities in China to examine how physicians currently perceive palliative care, and to identify specific goals for training as palliative care access expands. This study explored physicians’ perceptions of palliative care integration for advanced cancer patients in Changsha, China.MethodsWe conducted semi-structured qualitative interviews with physicians (n = 24) specializing in hematology or oncology at a tertiary hospital.ResultsMost physicians viewed palliative care as equivalent to end-of-life care, while a minority considered it possible to integrate palliative care with active treatment. Almost all physicians maintained separate conversations about palliative care with family members and patients, communicating more directly with family members than with patients about prognosis and goals of care. Physicians described experiencing ethical tension between the desire of family members to protect the patient from knowing they have advanced cancer, and the patient’s “right to decide” about palliative treatment. Physicians varied overall regarding perceptions of the role they should have in discussions about goals of care.ConclusionsAs palliative care access expands in China, medical training should encourage earlier integration of palliative care for advanced cancer, address ethical issues faced by physicians communicating about palliative care, and establish guidance on the role of the physician in discussions about goals of care.

Corporate debt default risk poses significant challenges in the business world, requiring a multifaceted approach for effective mitigation. This study, grounded in an ethical decision-making framework, investigates the influence of Confucian culture on shaping ethical corporate culture and managers’ moral capacity and its subsequent impact on corporate debt default risk. Our findings indicate that companies deeply influenced by Confucian culture tend to exhibit lower debt default risks. Specifically, companies that embrace Confucian values demonstrate an enhanced ethical corporate culture and heightened individual moral capacity. These factors play crucial roles in the ethical decision-making process, thereby reducing the likelihood of engaging in risky financial behaviors. Further analysis reveals that the inhibitory effect of Confucian culture on debt default risk is particularly pronounced in enterprises operating within regions characterized by poor integrity environments and weak product market competition. This inhibitory effect can lead to a reduction in the cost of corporate debt financing and the risk of stock price crashes. Overall, this study contributes to the understanding of the interplay between culture, business ethics, and corporate risk management.

Using a combination of co-citation and co-word analysis, this paper reviewed the intellectual structure of the sales ethics research domain and its development over time. This multi-method bibliometric analysis included 183 sales ethics articles published between 1990 and 2020. Using co-citation analysis, we identified intellectual clusters within the research domain and explored the evolution of these clusters across three decades. We further leveraged co-word analysis to identify core themes (keywords) and delineated the field’s changing landscape. The evolutionary trends and keyword network disconnections (i.e., structural holes) suggest promising areas for future research. In particular, our analyses identified potentially fruitful opportunities related to topics such as compensation, relationship marketing outcomes, salesperson job attitudes and well-being, training, sales force control, and sales technology.

Hui medicine is originated from Muslim medicine through Silk Road. This medicine is a unique Chinese traditional medicine system formed by the integration of traditional Islamic Arabia medicine and traditional Chinese medicine. This ethnic medicine is Sinicization of Islamic culture. It is also the cream of ancient Eastern and Western traditional medicine of China. Religion is very important for the Islamic faith population such as Hui nationality. Although Halal food, restaurants and schools are everywhere in Qinghai Xining city, there are not reports about the medical practice in the Muslim faith population. In this article, the in-patients are from Qinghai Kangle Hospital which is Hui medicine special hospital located in Hui majorities area in Qinghai Chengdong area. The data had been collected from January 1, 2020 to June 30, 2023 of COVID-19 period. This hospital served both Muslim and non-Muslim patients, and the medical doctors nurses and staffs are also come from Muslim and non-Muslim background, the education background is Western medicine and Traditional Chinese Medicine. Our results showed that there are no significant difference between the Muslim-believers and non Muslim-believers in their medical practice. The religion may not be important among the inpatients who served with Chinese Hui Medicine in Kangle Hospital.

As one of the greatest thinkers in ancient China, Zhu Xi was renowned for his philosophy but his achievements in historiography occupied an important position in traditional China as well. However, Zhu Xi’s historiography were only implied, but has not been discussed enough yet in comparison to his various works on philosophy. This thesis would like to focus on Zhu Xi’s historiography as a core topic to certify that Zhu Xi’s achievement on this field not only played an irreplaceable role among the grand system of his philosophy, but also on behalf of a special and significant historiographical sample in Chinese historiography that can be called “Neo-Confucian philosophy of history”. To achieve this aim, the thesis is divided into three parts. Their titles are “The Substance of Zhu Xi’s Historiography”, “The Functions of Zhu Xi’s Historiography ” and “The Functions of Zhu Xi’s Historiography ”. Zhu Xi’s historiography inherited “Three generations” and Confucius’ classics, and formed his philosophy on history, so it is the substance. Zhu Xi’s historiography also has many functions and expressions such as elucidate the way of running the state, establish the system and views on talents, which make his conception on history comes true, and really have positive effects on the society, so there are called the functions. More importantly, Zhu Xi’s great insight on history can be directly expressed via his writings and discussions, all of which were embodied in his works and discourses of historiography. In these three parts, the contents and spirits of Zhu Xi’s historiography can be described deeply and entirely, also seem to be more methodic.

Managerial myopia occurs when executives value short-term benefits to the extent that firm long-run development will be obstructed. Recent studies have shown that the locality effect plays an important role in managerial myopia—local United States chief executive officers who work near their home states are less likely to behave myopically because of more effective monitoring and greater reputation concern. In an emerging market, government policies play a more important role in the strategic planning enterprises. A local CEO may have better understanding of local government’s policies thus makes less short-term decisions. This article adds to this literature by testing whether local-province CEOs in China, i.e., the CEO’s native place or birthplace is in the same province as her company’s headquarters, are also far-sighted. Using data on 470 publicly listed non-state-owned Chinese firms from 2014 to 2018, supportive evidence has been found that non-local-province CEOs in China tend to cut R&D expenses for beating analyst forecasts, reversing earnings decline, or pursuing higher returns. This article also confirms social capital as one mechanism of Chinese local-province CEOs behaving less myopically. This investigation also adds to the literature by revealing a new mechanism that CEO locality in China has a positive and direct bearing on how governments support corporate innovation.

Optimization for vertical vibration performance of a rail-train coupling system is investigated in this paper with the introduction of inerters for both primary and secondary suspensions. A model of a typical Chinese passenger train that travels on a traditional rail with track, sleepers, and ballast is simulated. The goal is to improve the ride quality for the train and vibration attenuation for the rail system in response to track irregularities. Optimizations for only inertance and all suspension parameters are carried out by the particle swarm algorithm. Performance benefits for both the train and the rail system are demonstrated and suspension layouts with inerters connected in parallel and series are compared with the traditional one in both time domain and frequency domain.

In this paper, a repetitive control scheme of a 2-DOF robotic manipulator based on the improved cubic B-spline curve is proposed. Firstly, a repetitive controller for robotic manipulator is designed, which is composed of an iterative controller and disturbance observer. Then, an improved B-spline optimization scheme is introduced to divide the task of the robotic manipulator into three intervals. A correction function is added to each interval of cubic spline interpolation. Finally, a variety of cases are designed and simulated by MATLAB. The experimental results show that, compared with the conventional B-spline, the improved B-spline has better performance in tracking accuracy and smoothness of motion trajectory. By changing the mechanism of the manipulator, the cases of different weights and lengths are designed. The experimental results in these cases show that the proposed scheme can be applied to most of the 2-DOF robotic manipulator control systems.

On the basis of PM2.5 data of the national air quality monitoring sites, local population data, and baseline all-cause mortality rate, PM2.5-related health economic benefits of the Air Improvement Action Plan implemented in Wuhan in 2013–2017 were investigated using health-impact and valuation functions. Annual avoided premature deaths driven by the average concentration of PM2.5 decrease were evaluated, and the economic benefits were computed by using the value of statistical life (VSL) method. Results showed that the number of avoided premature deaths in Wuhan are 21,384 (95% confidence interval (CI): 15,004 to 27,255) during 2013–2017, due to the implementation of the Air Improvement Action Plan. According to the VSL method, the obtained economic benefits of Huangpi, Wuchang, Hongshan, Xinzhou, Jiang’an, Hanyang, Jiangxia, Qiaokou, Jianghan, Qingshan, Caidian, Dongxihu, and Hannan District were 8.55, 8.19, 8.04, 7.39, 5.78, 4.84, 4.37, 4.04, 3.90, 3.30, 2.87, 2.42, and 0.66 billion RMB (1 RMB = 0.1417 USD On 14 October 2019), respectively. These economic benefits added up to 64.35 billion RMB (95% CI: 45.15 to 82.02 billion RMB), accounting for 4.80% (95% CI: 3.37% to 6.12%) of the total GDP of Wuhan in 2017. Therefore, in the process of formulating a regional air quality improvement scheme, apart from establishing hierarchical emission-reduction standards and policies, policy makers should give integrated consideration to the relationship between regional economic development, environmental protection and residents’ health benefits. Furthermore, for improving air quality, air quality compensation mechanisms can be established on the basis of the status quo and trends of air quality, population distribution, and economic development factors.

A series of derivatives of the known thromboxane A2 prostanoid receptor antagonists, 3-sulfonamido)-5,6,7,8-tetrahydronaphthalen-1-yl)propanoic acid and 3-sulfonamido)ethyl)phenyl) propanoic acid, were synthesized in which the carboxylic acid functional group was replaced with substituted cyclopentane-1,3-dione bioisosteres. Characterization of these molecules led to the discovery of remarkably potent new analogues, some of which were considerably more active than the corresponding parent carboxylic acid compounds. Depending on the choice of the C2 substituent of the CPD unit, these new derivatives can produce either a reversible or an apparent irreversible inhibition of the human TP receptor. Given the potency and the long-lasting inhibition of TP receptor signaling, these novel antagonists may comprise promising leads for the development of antithromboxane therapies.

© 2016 Optical Society of America.We propose an all-solid-state tunable Bragg filter with a phase transition material as the defect layer. Bragg filters based on a vanadium dioxide defect layer sandwiched between silicon dioxide/titanium dioxide Bragg gratings are experimentally demonstrated. Temperature dependent reflection spectroscopy shows the dynamic tunability and hysteresis properties of the Bragg filter. Temperature dependent Raman spectroscopy reveals the connection between the tunability and the phase transition of the vanadium dioxide defect layer. This work paves a new avenue in tunable Bragg filter designs and promises more applications by combining phase transition materials and optical cavities.

© 2015 American Association for Cancer Research.Purpose: Myxopapillary ependymoma is a distinct histologic variant of ependymoma arising commonly in the spinal cord. Despite an overall favorable prognosis, distant metastases, subarachnoid dissemination, and late recurrences have been reported. Currently, the only effective treatment for MPE is gross-total resection. We characterized the genomic and transcriptional landscape of spinal ependymomas in an effort to delineate the genetic basis of this disease and identify new leads for therapy. Experimental Design: Gene expression profiling was performed on 35 spinal ependymomas, and copy number profiling was done on an overlapping cohort of 46 spinal ependymomas. Functional validation experiments were performed on tumor lysates consisting of assays measuring pyruvate kinase M activity, hexokinase activity, and lactate production. Results: At a gene expression level, we demonstrate that spinal grade II and MPE are molecularly and biologically distinct. These are supported by specific copy number alterations occurring in each histologic variant. Pathway analysis revealed that MPE are characterized by increased cellular metabolism, associated with upregulation of HIF1α. These findings were validated by Western blot analysis demonstrating increased protein expression of HIF1α, HK2, PDK1, and phosphorylation of PDHE1A. Functional assays were performed on MPE lysates, which demonstrated decreased PKM activity, increased HK activity, and elevated lactate production. Conclusions: Our findings suggest that MPE may be driven by a Warburg metabolic phenotype. The key enzymes promoting the Warburg phenotype: HK2, PKM2, and PDK are target-able by small-molecule inhibitors/activators, and should be considered for evaluation in future clinical trials for MPE.

The restaurant trade secrets protection system for the study of the construction of the center of gravity, analysis of a number of ways to protect trade secrets, its ultimate purpose is to establish a catering business technology-oriented development concept, to promote the catering enterprises bigger and stronger, therefore, to establish suitable for their own characteristics of a comprehensive trade secrets protection system should be the best choice for catering enterprises. On the basis of studying the protection system of bussiness confidentiality in the area of ​​diet, the paper tries to analyze several protection methods. The purpose is to encourage the view that technology is the most important and improve the enterprise's power in this area. It's reasonable for the enterprise of diet to set up the suitable and comprehensive protection system which just suits to its own characters