Qiu Wang

According to the extended mind thesis (EM) and other enactivism proposals, the extended conscious mind thesis (ECM) asserts that the material substrate of conscious mental states can extend beyond the boundary of the brain and into the environment. However, EM does not entail ECM. We examine the arguments for and against ECM, focusing on the supporting side's reasoning for the parity principle argument and sensorimotor interaction. We contend that their reasoning is flawed, and that they cannot guarantee the enactive effect in explaining all of the characters of consciousness. As a result, we suggest that we need a consensus on the theory of consciousness, one that can meet the conceivability and reflexivity criteria of consciousness, as a theoretical prerequisite for exploring ECM while also assisting us in understanding the nature of mind.

In correlated electron materials, electrons often self-organize and form a variety of patterns with potential ordering of charges, spins, and orbitals, which are believed to be closely connected to many novel properties of these materials including superconductivity, metal-insulator transitions, and the CMR effect. How these real-space patterns affect the conductivity and other properties of materials is one of the major challenges of modern condensed matter physics. Moreover, although the presence of static stripes is indisputable, the existence of fluctuating stripes in such compounds is a subject of great debate. Here we present the electronic excitations of La$_{2-2x}$Sr$_{1+2x}$Mn$_{2}$O$_{7}$ probed by angle-resolved photoemission, from which we demonstrate that a novel type of ordering, termed bi-stripes, can exhibit either static or fluctuating order as a function of temperature. We found that the static bi-stripe order is especially damaging to electrical conductivity, completely localizing the electrons in the bi-stripe regions, while the fluctuating stripes can coexist with mobile carriers. This physics drives a novel phase transition with colossal conductivity changes as a function of temperature. Our finding suggests that quantum stripes can give rise to electronic properties significantly different from their static counterparts. Inducing transition between them can turn on remarkable electronic phenomena, enriching our understanding of correlated electron systems as well as opening a window for potential applications in electronic devices.

Purpose: To assess noninvasive optical coherence tomography and optical Doppler tomography for early detection and evaluation of chemotherapy-induced oral mucositis. Experimental Design: Cheek pouches of 10 Syrian golden hamsters were imaged using OCT/ODT during development of chemotherapy-induced mucositis. I.p. injections of 5-fluorouracil and mechanical irritation induced oral lesions. At 2, 4, 7, and 11 days, one hamster was sacrificed and processed for histopathology. OCT images were visually examined; ODT results were semiquantified. Imaging data were compared with histologic findings. Results: During the development of mucositis, OCT/ODT identified the following events: change in epithelial thickness, loss of surface keratinized layer continuity, loss of epithelial and submucosal integrity, changes in axial blood flow velocity, and changes in blood vessel size. The semiquantitative imaging-based scoring system identified the severity of mucositis as defined by histopathology. The combination of imaging criteria used allowed for the detection of early, intermediate, and late mucositic changes. Imaging data gave higher scores compared with clinical scores early on, suggesting that the imaging-based diagnostic scoring was more sensitive to early mucositic change than the clinical scoring system. Once mucositis was established, imaging and clinical scores converged. Conclusion: OCT/ODT identified chemotherapy-induced oral changes before their clinical manifestation, and the proposed scoring system for oral mucositis was validated for the semiquantification of mucositic change. © 2007 American Association for Cancer Research.

© 2015 Macmillan Publishers Limited All rights reserved. Genome-wide gene expression measurements have enabled comprehensive studies that integrate the changes of gene expression and phenotypic information to uncover their novel associations. Here we reported the association analysis between psychophysical phenotypes and genome-wide gene expression changes in human adaptation to one of the most extreme climates on Earth, the Antarctic Dome Argus. Dome A is the highest ice feature in Antarctica, and may be the coldest, driest and windiest location on earth. It is considered unapproachable due to its hostile environment. In 2007, a Chinese team of 17 male explorers made the expedition to Dome A for scientific investigation. Overall, 133 psychophysical phenotypes were recorded, and genome-wide gene expression profiles from the blood samples of the explorers were measured before their departure and upon their arrival at Dome A. We found that mood disturbances, including tension, depression, anger and fatigue, had a strong, positive, linear relationship with the level of a male sex hormone, testosterone, using the Pearson correlation coefficient analysis. We also demonstrated that significantly lowest-level Gene Ontology groups in changes of gene expression in blood cells with erythrocyte removal were consistent with the adaptation of the psychophysical characteristics. Interestingly, we discovered a list of genes that were strongly related to significant phenotypes using phenotype and gene expression PCC analysis. Importantly, among the 70 genes that were identified, most were significantly related to mood disturbances, where 42 genes have been reported in the literature mining, suggesting that the other 28 genes were likely novel genes involved in the mood disturbance mechanism. Taken together, our association analysis provides a reliable method to uncover novel genes and mechanisms related to phenotypes, although further studies are needed.

© 2015 Elsevier Inc. β-adrenergic signaling pathways mediate key aspects of cardiac function. Its dysregulation is associated with a range of cardiac diseases, including dilated cardiomyopathy. Previously, we established an iPSC model of familial DCM from patients with a mutation in TNNT2, a sarcomeric protein. Here, we found that the β-adrenergic agonist isoproterenol induced mature β-adrenergic signaling in iPSC-derived cardiomyocytes but that this pathway was blunted in DCM iPSC-CMs. Although expression levels of several β-adrenergic signaling components were unaltered between control and DCM iPSC-CMs, we found that phosphodiesterases 2A and PDE3A were upregulated in DCM iPSC-CMs and that PDE2A was also upregulated in DCM patient tissue. We further discovered increased nuclear localization of mutant TNNT2 and epigenetic modifications of PDE genes in both DCM iPSC-CMs and patient tissue. Notably, pharmacologic inhibition of PDE2A and PDE3A restored cAMP levels and ameliorated the impaired β-adrenergic signaling of DCM iPSC-CMs, suggesting therapeutic potential. In this paper, Wu etal. profiled the β-adrenergic signaling properties in human iPSC-CMs and demonstrated novel epigenetic mechanisms that underlie the compromised β-adrenergic signaling in DCM, a common cause of heart failure and cardiac transplantation. These results enhance our understanding of DCM pathogenesis and may uncover new therapeutic targets.

Marxist Historiographies is the first book to examine the ebb and flow of Marxist historiography from a global and cross-cultural perspective. Since the eighteenth century, few schools of historical thought have exerted a more lasting impact than Marxism, and this impact extends far beyond the Western world within which it is most commonly analysed. Edited by two highly respected authors in the field and taking a truly global perspective on this topic, Marxist Historiographies demonstrates clearly the breadth and depth of Marxism's influence in historical writing throughout the world and is essential reading for all students of historiography.

In the May Fourth era of the 1910s and 1920s, Confucius' image was associated closely with the conservative political forces that were increasingly regarded by many as the cause of the challenges the newly founded Republic was facing. With respect to Confucius, Hu Shi believed that the critical attitude engendered in the May Fourth era had brought Confucius down from a high pedestal and put him on a par with the contemporaries of his time. Hu Shi's main assessment of Confucius as an ancient philosopher was shown in his doctoral dissertation and the later published A History of Ancient Chinese Philosophy, both appeared in the May Fourth era. During the May Fourth era, the interest in distinguishing “historical Confucius” from “iconic Confucius” was conducive to the emergence of the National Studies Movement, led by Zhang Taiyan, Hu Shi, Liang Qichao, and others.

Taking Chun-chieh Huang’s ruminations on the defining character of Chinese historical thinking as a starting point, this essay discusses the ways in which historical cultures and traditions are compared and contrasted and explores some new ways of thinking. It argues that cultural comparisons often constitute two-way traffic and that attempts to characterize one historical culture, such as that of China, are often made relationally and temporally. When the Chinese tradition of historiography is perceived and presented in the West, it has been regarded more or less as a counterexample against which the “unique” traits of Western historical thinking are thrown into relief. Given the hegemonic influence of Western scholarship in modern times, latter-day Chinese historians also valorize the East–West dichotomy. A closer look at this dichotomy, or the characterization of both cultures, reveals that it is not only relative but also relational and temporal. When the modern Chinese appeared impressed by the rigor of Rankean critical historiography, for example, they were essentially attempting to rediscover their own cultural past, for example, the eighteenth-century tradition of evidential learning, in adapting to the changing world. Our task today, the essay contends, is to historicize the specific context within which cultural comparisons are made and to go beyond readily accepted characterizations in order to reassess certain elements in a given culture, to apply historical wisdom, and to cope with the challenges we now face