Xin Yu Zhang

Objectives: The aim of the current study was to differentiate between neural activity that represents neural anomalies that are responsible for persistent developmental stuttering from the activity that is a result of compensating for stuttering. This was done by investigating alterations to the intrinsic functional architecture of speech-language processes of patients with PDS before and after a short-term intervention. Methods: The resting-state functional connectivity and cortical thickness were examined before and after the intervention. The structural data were used to validate the functional results. Fifteen stuttering patients who received intervention, 13 stuttering patients who did not receive intervention, and 13 fluent controls participated. Results: Before the intervention, both groups of PDS patients showed significant RSFC and cortical thickness reductions in the left pars-opercularis and RSFC increases in the cerebellum, as compared to fluent controls. The intervention was effective in reducing stuttering in PDS- patients and lowering their RSFC in the cerebellum to the level of fluent controls. The intervention effect was specific to the PDS-group. The intervention did not change RSFC and cortical thickness in the left PO, which remained at its preintervention level. Conclusions: The results suggest that the left PO is a locus where the intrinsic functional architecture of speech-language processes is altered in PDS patients, suggesting an etiologic role of this region in PDS. The cerebellum showed intervention-induced neural reorganization, suggesting a compensatory response when stuttering occurs. Copyright © 2012 by AAN Enterprises, Inc.

© 2015 Taylor & Francis. This analysis compares the climate impacts over North America during winter associated with various El Niño-Southern Oscillation indices, including the Niño 3.4 index, the leading tropical Pacific outgoing longwave radiation and sea surface temperature covariability, and the eastern Pacific and central Pacific types of ENSO identified from both partial-regression-empirical orthogonal function and regression-EOF approaches. The traditional Niño 3.4 SST index is found to be optimal for monitoring the tropical Pacific OLR-SST covariability and for the tropical SST impact on North America. The circulation anomalies associated with the Niño 3.4 index project on both the Pacific/North American and Tropical/Northern Hemisphere patterns. The ENSO associated with the PNA tends to come from both the EP and CP ENSOs, whereas that associated with the TNH comes more from the EP ENSO. The variability of ENSO significantly affects North American temperature and precipitation, as well as temperature and precipitation extremes. For either the EP or CP types of ENSO, qualitatively similar patterns of climate and climate extreme anomalies are apparent associated with the indices identified by the two EOF approaches, with differences mainly in the anomalous amplitude. The anomalous patterns are generally field significant over North America for the EP ENSO but not field significant for the CP ENSO. The circulation anomalies associated with ENSO are reinforced and maintained by synoptic vorticity fluxes in the upper troposphere. The anomalous surface temperature is mainly determined by the anomalies in surface radiative heating in the face of upward surface longwave radiative damping. The precipitation anomalies are supported by the vertically integrated moisture transport. The differences in atmospheric circulation, surface temperature, and precipitation among the various ENSO indices, including the intensity and spatial structure of the fields, can be attributed to the corresponding differences in synoptic eddy vorticity forcing, surface radiative heating, and vertically integrated moisture transport.

Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 copy number variation in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-derived subcultures. We then characterized the biology of three syngeneic glioma cultures dominated by different Chr7-aneuploid cell types. We found phenotypic divergence for cells following Chr7 missegregation, which benefited overall tumor growth in vitro and in vivo. Mathematical modeling suggested the involvement of chromosome instability and interactions among cell subpopulations in restoring the optimal equilibrium of tumor cell types. Both our experimental data and mathematical modeling demonstrated that the complexity of tumor heterogeneity could be enhanced by the existence of chromosomes with structural abnormality, in addition to their mis-segregations. Overall, our findings show, for the first time, the involvement of chromosome instability in maintaining tumor heterogeneity, which underlies the enhanced growth, persistence and treatment resistance of cancers. © 2013 Hu et al.

In this paper, we discuss the weakness of current action languages for sensing actions with respect to modeling domains with multi-valued fluents. To address this problem, we propose a language with sensing actions and multi-valued fluents, called AMK, provide a transition function based semantics for the language, and demonstrate its use through several examples from the literature. We then define the entailment relationship between action theories and queries in AMK, denoted by ⊧AMK, and discuss some properties about AMK.