James Marcum

Medicine is facing several significant challenges as the twenty-first century unfolds, which represent barriers or limitations that threaten to cripple the advancement of medicine and its practice. One of the responses to these challenges is the emergence of systems medicine. And one of the more pertinent challenges is identifying and clarifying systems medicine's conceptual and theoretical foundations. The present book represents a sustained effort to examine this challenge and to map the terrain by which to engage it and to pursue possible solutions. This conceptual and theoretical challenge in particular needs to be addressed to ensure the future success of systems medicine. To that end the book explores the conceptual and theoretical foundations of systems medicine, including the major concepts of organicism, emergence, and robustness, and contrasts these concepts to those for biomedicine, including mechanism, resultant, and homeostasis. Moreover, this challenge is critical because its resolution provides the intellectual scaffolding necessary for structuring the concepts and theories required to understand and explain more adequately or completely biological, physiological, and pathological mechanisms and processes. Importantly, with a robust conceptual and theoretical scaffolding, systems medicine must be implemented interdisciplinary not only within the medical community but also within the social and political communities, which the COVID-19 pandemic made so painfully obvious.