Marco Buzzoni

The operational perspective here defended permits a reflexive-transcendental point of view that sharply distinguishes the two concepts, while, at the same time, maintaining the connection between them. On the one hand, simply imagining that the experimental apparatus, counterfactually anticipated in a thought experiment, has really been constructed is sufficient to erase any difference between thought and real experiments. On the other hand, this very ‘imagining’, this capacity of the mind to assume every real entity as a possible entity, underpins the difference in principle – a properly transcendental difference – between thought and real experiments. This difference, however, implies the intimate association between experiment and thought experiment: All thought experiments must be thought of as translatable into real ones, and all real experiments as realisations of thought ones. What thought experiments have over and above real experiments is the mere fact that they exist in a purely hypothetical sphere; what real have over and above thought experiments is the mere fact that they overstep the sphere of the possible, in the experiment’s real execution.

Thought experiments de facto play many different roles in biology: economical, ethical, technical and so forth. This paper, however, is interested in whether there are any distinctive features of biological TEs as such. The question may be settled in the affirmative because TEs in biology have a function that is intimately connected with the epistemological and methodological status of biology. Peculiar to TEs in biology is the fact that the reflexive, typically human concept of finality may be profitably employed to discover mechanical-experimental causal relations in all living beings—with the obvious caveat that we do not hypostatise and interpret this concept as an ontological quality, since this would land one in an implicitly animistic, pre-Galilean view of nature. From a methodical point of view, the concept of finality is an essential assumption as well as a powerful heuristic tool in the practice of biology, that is, in the investigation of living beings in an intersubjectively testable and reproducible way.

Hermeneutic and anti-hermeneutic sides in the debate about psychoanalysis are entangled in an epistemological and methodological antinomy, here exemplified by Grünbaum's and Spence's paradigmatic views. Both contain a partial element of truth, which they assert dialectically one against the other (§§ 1 and 2). This antinomy disappears only by reconciling an operationalist approach with man's ability to suspend the effectiveness of the‘laws’ applied to him (§ 3). The hermeneutic way in which the technical-operational criterion of truth works in psychoanalysis demands that clinical and extra-clinical testing methods work synergically, through a fruitful self-correcting strategy, grounded on the very psychoanalytic object: the unconscious (§ 4).

Operationalism and theoretical entities. The thesis of the“theory ladenness” of observation leads to an antinomy. In order to solve this antinomy a technical operationalism is sketched, according to which theories should in principle not contain anything that cannot be reduced to technical procedures. This implies the rejection of Quine's underdeterminacy thesis and of many views about the theoretical-observational distinction, e.g. neopositivistic views, van Fraassen's view, Sneed-Stegmüller's view. Then I argue for the following theses: 1. All scientific concepts are theory laden in the sense that they allow us to anticipate possible experiences, but they have to be in principle fully observable, i.e. integrally convertible into operational-technical applications. 2. The observation/theory distinction can be maintained as a historical one: what is observable depends on the instruments that are available at any stage of the development of science. 3.In principle theoretical entities are empirically real in Hacking's sense. However, some aspects of Hacking's realism are to be criticized. Theoretical entities are to be resolved into the totality of the interrelated properties accessible to us by means of theoretical points of view embodied in scientific instruments.