Murali Ramachandran

In his influential paper 'Speaker's Reference and Semantic Reference', Kripke defends Russell's theory of descriptions against the charge that the existence of referential and attributive uses of descriptions reflects a semantic ambiguity. He presents a purely defensive argument to show that Russell's theory is not refuted by the referential usage and a number of methodological considerations which apparently tell in favour of Russell's unitary theory over an ambiguity theory. In this paper, I put forward a case for the ambiguity theory that thwarts Kripke's defensive strategy and argue that it is not undermined by any of his methodological points.

An ‘inverted’ reasoner is someone who finds the inferences we find easy, inversely difficult, and those that we find difficult, inversely easy. The notion was initially introduced by Christopher Cherniak in his book, Minimal Rationality, and appealed to by Stephen Stich in The Fragmentation of Reason. While a number of difficulties have been noted about what reasoning would amount to for such a reasoner, what has not been brought out in the literature is that such a reasoner is in fact logically impossible. This is what I hope to demonstrate in this paper

Both W9 and OP3‐4 were known to bind the receptor activator of NF‐κB ligand (RANKL), inhibiting osteoclastogenesis. Recently, both peptides were shown to stimulate osteoblast differentiation; however, the mechanism underlying the activity of these peptides remains to be clarified. A primary osteoblast culture showed that rapamycin, an mTORC1 inhibitor, which was recently demonstrated to be an important serine/threonine kinase for bone formation, inhibited the peptide‐induced alkaline phosphatase activity. Furthermore, both peptides promoted the phosphorylation of Akt and S6K1, an upstream molecule of mTORC1 and the effector molecule of mTORC1, respectively. In the in vivo calvarial defect model, W9 and OP3‐4 accelerated BMP‐2‐induced bone formation to a similar extent, which was confirmed by histomorphometric analyses using fluorescence images of undecalcified sections. Our data suggest that these RANKL‐binding peptides could stimulate the mTORC1 activity, which might play a role in the acceleration of BMP‐2‐induced bone regeneration by the RANKL‐binding peptides.

[full article, abstract in English; abstract in Lithuanian] Fred Dretske motivates his denial of epistemic closure by way of the thought that the warrant for the premises of a valid argument need not transfer to the argument’s conclusion. The failure-of-transfer-of-warrant strategy has also been used by advocates of epistemic closure as a foil to Michael McKinsey’s argument against the compatibility of first person authority and semantic externalism, and also to illuminate, more generally, why certain valid arguments appear ill-suited for the purpose of establishing their conclusions. This paper takes re-examines some of the central attempts to explain transmission-failure, and a central line of objection to the strategy from Begging-the-Question theorists. The ultimate goal of this paper is to promote a decidedly Dretskean explanation of the unpersuasiveness of the said arguments.

Timothy Williamson (2000) reckons that hardly any mental state is luminous, i.e. is such that if one were in it, then one would invariably be in a position to know that one was. This paper examines an argument he presents against the luminosity of feeling cold, which he claims generalizes to other phenomenal states, such as e.g. being in pain. As we shall see, the argument fails. However, our deliberations do yield two anti-luminosity results: a simple refutation of the claim that one invariably knows whether one feels cold or not,1 and a counterexample to the luminosity of knowing—in effect, a counterexample to the (KK)- principle.