Xin Zhang

Science and technology drive research progress but also introduce growing risks, value conflicts and ethical challenges. Science and technology ethics review committees (STERCs) serve as key institutional mechanisms to ensure that scientific activities comply with ethical principles and professional norms. However, the establishment of STERCs worldwide remains at an early developmental stage, and structured, systematic criteria for evaluating their quality are largely absent. This study aims to develop a structured evaluation indicator system for STERCs and to explore its preliminary applicability. This study conducted a literature review and qualitative interviews to develop a preliminary evaluation indicator system, which was organized using Donabedian’s three-dimensional framework of structure, process, and outcome. The final indicator system was established after two rounds of expert consultation. The preliminary self-assessment data were collected from 80 medical institutions and 19 companies across 14 cities in Hunan Province. Both rounds of the Delphi consultation achieved a 100% response rate. The mean authoritative coefficient (Cr) was 0.900, while familiarity (Cs) and judgment basis (Ca) scores were 0.867 and 0.933, respectively. Kendall’s coefficient of concordance (Kendall’s W) was 0.300 (p < 0.001) in round one and 0.213 (p < 0.001) in round two. The final evaluation indicator system consisted of three first-level indicators, nine second-level indicators and 52 third-level indicators. This study proposes a unified framework for science and technology ethics review, integrating activities involving humans, animals, and other potential technological risks into a single evaluation system. The indicator system supports institutional self-assessment, promotes standardization, and guides continuous improvement. Preliminary findings indicate its feasibility and internal consistency, but these results should be interpreted cautiously due to the limited sample scope and reliance on self-reported data.

Clinical ethics consultations (CECs) play an important role in resolving ethical issues in clinical practice worldwide. The government has encouraged the development of CECs in China to address the ethical challenges arising in prenatal diagnosis. So far, the current state and challenges facing CEC remain understudied. This study aimed to explore the perspectives of employees on ethics committees for prenatal diagnosis in 13 medical institutions in Hunan Province, China. Twenty-eight employees participated in interviews. Our qualitative approach employed content analysis to identify major themes in interviewees’ responses, which covered the composition and vision of their prenatal diagnosis ethics committee, as well as the challenges they faced. The results show that CEC in China is in an exploratory stage, with models for CEC composition, and workflow varying significantly. Therefore, we propose the future direction of efforts to improve CECs, including improving CEC working mechanisms and operating procedures, strengthening ethical training for healthcare workers and ethics committee employees, and developing more specific ethical guidance based on the accumulated experiences of ethics committee employees in the early development of CEC for prenatal diagnosis.

The international community has proposed a comprehensive strategy to prevent congenital abnormalities. And China, with a high incidence of congenital diseases, has implemented measures including prenatal screening and diagnosis to reduce the morbidity of congenital abnormalities. However, ethical challenges arise in the practice of prenatal screening and diagnosis among healthcare professionals. Five focus group discussions were conducted with twenty-four health professionals working in maternal and child health services in Hunan Province, China, to explore the ethical challenges they encountered in prenatal testing decision-making and information disclosure practices, as well as their views on these challenges. Participants were selected through purposive sampling, ensuring maximum demographic diversity. Three main themes were identified: 1) balancing between information disclosure and privacy protection; 2) patient-oriented decision-making and tensions within family-oriented decision-making; 3) the disparity between the limited help clinical ethics committees (CECs) can provide and professionals’ need for CECs. Ethical norms for information disclosure and autonomous decision-making within prenatal screening and diagnostic institutions must be established. Utilizing CECs is crucial to guide professionals in delivering prenatal testing services while simultaneously focusing on targeted improvement of communication skills among these professionals.

People are known for good predictions in domains they have rich experience with, such as everyday statistics and intuitive physics. But how well can they predict for problems they lack experience with, such as the duration of an ongoing epidemic caused by a new virus? Amid the first wave of COVID-19 in China, we conducted an online diary study, asking each of over 400 participants to predict the remaining duration of the epidemic, once per day for 14 days. Participants’ predictions reflected a reasonable use of publicly available information but were meanwhile biased, subject to the influence of negative affect and future time perspectives. Computational modeling revealed that participants neither relied on prior distributions of epidemic durations as in inferring everyday statistics, nor on mechanistic simulations of epidemic dynamics as in computing intuitive physics. Instead, with minimal experience, participants’ predictions were best explained by similarity-based generalization of the temporal pattern of epidemic statistics. In two control experiments, we further confirmed that such cognitive algorithm is not specific to the epidemic scenario and that minimal and rich experience do lead to different prediction behaviors for the same observations. We conclude that people generalize patterns in recent history to predict the future under minimal experience.

This paper examines Margaret Drabble's The Millstone as a critical intervention in feminist debates on reproductive agency in postwar Britain. It argues that the novel redefines motherhood not as a biologically determined role but as a consciously chosen identity shaped by lived experience, social class and institutional power. Through the protagonist Rosamund Stacey, Drabble challenges essentialist conceptions of womanhood by portraying motherhood as a site of negotiation, resistance and selfformation. Drawing on Michel Foucault's concept of disciplinary power and Judith Butler's theory of gender performativity, the paper explores how medical institutions discipline the female body and how maternal identity is performed through care and choice. By presenting diverse female experiences, Drabble challenges monolithic narratives of both motherhood and femininity.

Purpose While short-video platforms have gained prominence in health communication, limited research has investigated their role in physician-led health messaging. The objective of this study is to enhance understanding of how celebrity physicians in China use Douyin for health communication and audience engagement. Design/methodology/approach A quantitative content analysis was conducted on 240 videos from 30 celebrity physicians, collected between 6 November and 6 December 2023. A coding framework comprising 4 main categories and 41 subcategories was developed based on message sensation value theory to assess account engagement, video content, video format and health-care promotion. The coding process was completed in January 2024. Findings User engagement largely remained at the level of likes and saves, with fewer deeper interactions such as comments and shares. Results also indicate viewers strongly preferred health advice content featuring concise oral narration by a single physician, short video duration, original background music and clear subtitles. Educational and humorous presentations significantly boosted user engagement. However, ethical concerns emerged, notably regarding information accuracy and transparency in advertisements, potentially influencing audience trust toward celebrity physician-led content. Originality/value The findings contribute to the growing body of literature on digital health communication and offer practical recommendations for both celebrity and non-celebrity physicians to enhance their health messaging strategies on Douyin and similar platforms.

Objectives: The aim of the current study was to differentiate between neural activity that represents neural anomalies that are responsible for persistent developmental stuttering from the activity that is a result of compensating for stuttering. This was done by investigating alterations to the intrinsic functional architecture of speech-language processes of patients with PDS before and after a short-term intervention. Methods: The resting-state functional connectivity and cortical thickness were examined before and after the intervention. The structural data were used to validate the functional results. Fifteen stuttering patients who received intervention, 13 stuttering patients who did not receive intervention, and 13 fluent controls participated. Results: Before the intervention, both groups of PDS patients showed significant RSFC and cortical thickness reductions in the left pars-opercularis and RSFC increases in the cerebellum, as compared to fluent controls. The intervention was effective in reducing stuttering in PDS- patients and lowering their RSFC in the cerebellum to the level of fluent controls. The intervention effect was specific to the PDS-group. The intervention did not change RSFC and cortical thickness in the left PO, which remained at its preintervention level. Conclusions: The results suggest that the left PO is a locus where the intrinsic functional architecture of speech-language processes is altered in PDS patients, suggesting an etiologic role of this region in PDS. The cerebellum showed intervention-induced neural reorganization, suggesting a compensatory response when stuttering occurs. Copyright © 2012 by AAN Enterprises, Inc.

© 2015 Taylor & Francis. This analysis compares the climate impacts over North America during winter associated with various El Niño-Southern Oscillation indices, including the Niño 3.4 index, the leading tropical Pacific outgoing longwave radiation and sea surface temperature covariability, and the eastern Pacific and central Pacific types of ENSO identified from both partial-regression-empirical orthogonal function and regression-EOF approaches. The traditional Niño 3.4 SST index is found to be optimal for monitoring the tropical Pacific OLR-SST covariability and for the tropical SST impact on North America. The circulation anomalies associated with the Niño 3.4 index project on both the Pacific/North American and Tropical/Northern Hemisphere patterns. The ENSO associated with the PNA tends to come from both the EP and CP ENSOs, whereas that associated with the TNH comes more from the EP ENSO. The variability of ENSO significantly affects North American temperature and precipitation, as well as temperature and precipitation extremes. For either the EP or CP types of ENSO, qualitatively similar patterns of climate and climate extreme anomalies are apparent associated with the indices identified by the two EOF approaches, with differences mainly in the anomalous amplitude. The anomalous patterns are generally field significant over North America for the EP ENSO but not field significant for the CP ENSO. The circulation anomalies associated with ENSO are reinforced and maintained by synoptic vorticity fluxes in the upper troposphere. The anomalous surface temperature is mainly determined by the anomalies in surface radiative heating in the face of upward surface longwave radiative damping. The precipitation anomalies are supported by the vertically integrated moisture transport. The differences in atmospheric circulation, surface temperature, and precipitation among the various ENSO indices, including the intensity and spatial structure of the fields, can be attributed to the corresponding differences in synoptic eddy vorticity forcing, surface radiative heating, and vertically integrated moisture transport.

Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 copy number variation in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-derived subcultures. We then characterized the biology of three syngeneic glioma cultures dominated by different Chr7-aneuploid cell types. We found phenotypic divergence for cells following Chr7 missegregation, which benefited overall tumor growth in vitro and in vivo. Mathematical modeling suggested the involvement of chromosome instability and interactions among cell subpopulations in restoring the optimal equilibrium of tumor cell types. Both our experimental data and mathematical modeling demonstrated that the complexity of tumor heterogeneity could be enhanced by the existence of chromosomes with structural abnormality, in addition to their mis-segregations. Overall, our findings show, for the first time, the involvement of chromosome instability in maintaining tumor heterogeneity, which underlies the enhanced growth, persistence and treatment resistance of cancers. © 2013 Hu et al.

This study investigated the effects of culture and collaborative discussion on Chinese and American children’s moral reasoning in reflective essays that they composed about a moral and practical dilemma. In contrast to American children who frequently expressed egocentric concerns, Chinese children exhibited altruistic tendencies and expressed more concern for maintaining in-group harmony, which are the core values advocated in collectivist culture. Collaborative discussion promoted children’s moral reasoning in both cultures, leading to significantly more consideration of the principles of being honest, having empathy for others, keeping promises, honoring friendship, being trustworthy, and not betraying others by tattling.

In this paper, we discuss the weakness of current action languages for sensing actions with respect to modeling domains with multi-valued fluents. To address this problem, we propose a language with sensing actions and multi-valued fluents, called AMK, provide a transition function based semantics for the language, and demonstrate its use through several examples from the literature. We then define the entailment relationship between action theories and queries in AMK, denoted by ⊧AMK, and discuss some properties about AMK.

Public education in museums has the interdisciplinary nature of STEAM education contemporary learning. In the contemporary learning process of the public, digital museums can rely on mobile terminals to provide people with opportunities for mobile learning. Especially since the global outbreak of COVID-19, many offline museums have been forced to close their doors or impose restrictions. How to use digital museums to better carry out the learning experience of visitors is a problem worthy of attention. Effective dissemination of visual information can help digital museums conduct educational activities more efficiently. The purpose of this study was to explore a research method for visual evaluation of visitors’ learning experiences in digital museums. The visual evaluation of visitors in the digital museum learning experience involves the layout of exhibition content, the form of exhibition space, and the way of display of exhibits. Through eye-tracking engineering experiments, we obtain and analyze the visual data of visitors during the educational experience of the digital museum to form an accurate evaluation. This method can be used to assess the visual satisfaction of visitors with the educational experience of a digital museum in mobile learning. This kind of evaluation research can provide strong data support and design optimization direction guidance for the development of digital museum public education.

White LEDs, which have been widely used in the urban street lighting, are increasingly applied to replace traditional HPS lamps with a lower CCT. Generally, studies on the CCT of street lighting focus on providing safe functional lighting for vehicle drivers. However, it is still unknown how the street light color can affect pedestrians’ perception and preferences with respect to lighting levels and ambient temperature.In this study, a wide range of CCTs was measured for urban street lighting in Beijing, China, for example. And the transition from traditional HPS lamps to LEDs lacks a reference street lighting standard for CCT. The study aims to conduct a cross-sensory test to evaluate urban street lighting with multiple combinations of CCT values and illuminance levels according to pedestrians’ visual perception and psychological preferences.A total of 18 night street lighting scenes with six CCT values and three illuminance levels were first selected in Beijing city, and then HDR videos of these scenes were taken from the view of pedestrians to conduct psychological experiments in an indoor environment with three ambient temperatures. A total of 77 university students were invited to assess videos of the 18 lighting scenes in terms of seven factors, such as lighting brightness, color temperature sensation, light color preference, sense of safety, recognition, comfort, and overall preference. Several key findings were achieved as follows. The CCT of urban street lighting can have significant effects on the visual psychological perceptions of participants. There was a significant interaction between CCT, illuminance, and ambient temperature on the visual psychological performances of participants. The higher ambient temperature will deliver the higher level of overall preference for the street lighting with medium and high CCT, and the perception of warmer light color. There was a strong correlation found between participants’ light color preference, comfort, and overall preferences.

To effectively reduce the homework burden and off-campus training burden of students in the compulsory education stage in China, China adopts the double reduction policy to carry out corresponding governance in the field of education. This study aims to explore the public's psychological cognition of the current education system under the implementation of the double reduction policy. The public's opinion data on education concepts under the implementation of the double reduction policy are collected, then the SPSS software and Amos software to quantitatively analyze the public's educational concept data are used, and a corresponding structural model equation to analyze the public's opinion on the implementation of the double reduction policy is established. The psychological concepts of all aspects of education are observed, the public's psychological views on education under the implementation of the double reduction policy are finally obtained, the ideological connotation of popularizing the double reduction policy for the general public is provided, and the balanced development of the domestic education system for the implementation of the double reduction policy is ensured. Two suggestions are made in order to provide a corresponding reference for the public's psychological cognition research on the current education system under the implementation of the double reduction policy.

This study aimed to provide evidence of validity and reliability for the Perceived Mattering Questionnaire-Physical Education developed by Richards et al. for the Chinese physical education teachers. The PMQ-PE consisted of two factors with four items in each, measuring four dimensions. PMQ-PE in Chinese was validated among 1,278 elementary and secondary school PE teachers in China, of whom 59.0% were secondary PE teachers and 70.2% were males. Confirmatory factor analysis with the entire sample found a poor model fit. Then exploratory factor analysis using half of the sample indicated there was only one factor in PMQ-PEC. CFA of the other half of the sample suggested a one-factor model with the elimination of three unfitted items showed a better fitness to the data. Cronbach's alpha value was also acceptable. The final version of PMQ-PEC included five items with one factor that demonstrated acceptable validity and reliability and was deemed acceptable among Chinese PE teachers after the above modifications were made.

People as group members tend to exhibit a partial attitude to either conform to the dominant group view or form beliefs—such as climate change denial and religious belief—based on other ingroup members’ testimony when the evidence for such a belief is insufficient. Philosophers have conceptualized this phenomenon of ingroup attitudes in terms of belief. In this paper, I argue that reliance, a cognitive attitude that is goal-oriented and primarily regulated by pragmatic concerns, is more fitting to illuminate cases of ingroup attitudes. Framing the discussion of ingroup attitudes in terms of reliance has three virtues: it captures the volitional aspect of the ingroup attitude that the norm governing belief fails to offer; it explains the indifference to evidence that occurs in cases of ingroup attitudes; and it resolves the seeming irrationality in acting against what one believes.

With the expansion of the digital business line, the network flow behind the digital power grid is also exploding. To prevent network congestion, this article proposes a novel network flow forecasting model, which is composed of variational mode decomposition, GRU-xgboost block, and a forecasting adjustment block, to grasp the changing patterns and trends of network flow in advance, and to formulate reasonable and effective flow management strategies and meet the requirements of users for network service quality. The network flow series in power grid enterprise always contain complex patterns and outliers, and VMD is applied to adaptively process complex net flow time series into several subseries with simpler patterns. A GRU-xgboost block is designed to reconstruct the features of historical series. Then, xgboost model is applied to generate predictions for all decomposed subsignals. For the final predictions, we design a forecasting adjustment block to further remove the influence of random noise. Finally, the empirical results show the superior performance of the proposed model on network flow forecasting task.

Objective: The aim of the current study was to investigate the alterations in the neural networks of patients with temporal lobe epilepsy during working memory encoding.Methods: Patients with TLE and healthy volunteers completed a WM task, during which 34-channel electroencephalogram signals were recorded. The neural networks during WM encoding were calculated in TLE patients with and without WM deficits.Results: Functional connectivity strength decreased, and the theta network was altered in the TLE-WM group, although no significant differences in clinical features were observed between the TLE-N and TLE-WM groups.Conclusions: Not all patients with TLE present with cognitive impairments and alterations in the theta network were identified in TLE patients with functional cognitive deficits.Significance: The theta network may represent a sensitive measure of cognitive impairment and could predict cognitive outcomes among patients with TLE.