Leemon McHenry

In this monograph, I argue that Whitehead's metaphysics provides a more adequate basis for achieving a unification of physical theory than a traditional substance metaphysics. I investigate the influence of Maxwell's electromagnetic field, Einstein's theory of relativity and quantum mechanics on the development of the ontology of events and compare Whitehead’s theory to his contemporaries, C. D. Broad and Bertrand Russell, as well as another key proponent of this theory, W. V. Quine. In this manner, I defend the naturalized and speculative approach to metaphysics as opposed to analytical and linguistic methods that arose in the 20th century.

Ghostwriting for medical journals has become a major, but largely invisible, factor contributing to the problem of credibility in academic medicine. In this paper I argue that the pharmaceutical marketing objectives and use of medical communication firms in the production of ghostwritten articles constitute a new form of sophistry. After identifying three distinct types of medical ghostwriting, I survey the known cases of ghostwriting in the literature and explain the harm done to academic medicine and to patients. Finally, I outline steps to address the problem and restore the integrity of the medical literature

Nicholas Maxwell's provocative and highly-original philosophy of science urges a revolution in academic inquiry affecting all branches of learning, so that the single-minded pursuit of knowledge is replaced with the aim of helping people realize what is of value in life and make progress toward a more civilized world. This volume of essays from an international, interdisciplinary group of scholars engages Maxwell in critical evaluation and celebrates his contribution to philosophy spanning forty years. Several of the contributors, like Maxwell, took their inspiration from Sir Karl Popper’s philosophy of science and were connected to the department he created at the London School of Economics. In the introductory chapter, Maxwell provides an overview of his thought and then defends his views against objections in a concluding essay.

The current situation in medicine has been described as a crisis of credibility, as the profit motive of industry has taken control of clinical trials and the dissemination of data. Pharmaceutical companies maintain a stranglehold over the content of medical journals in three ways: (1) by ghostwriting articles that bias the results of clinical trials, (2) by the sheer economic power they exert on journals due to the purchase of drug advertisements and journal reprints, and (3) by the threat of legal action against those researchers who seek to correct the misrepresentation of study results. This paper argues that Karl Popper's critical rationalism provides a corrective to the failure of academic freedom in biomedical research.

The idea that prescribing physicians should be guided by the most reliable scientific evidence seems obvious, but the actual methodology of evidence-based medicine was only introduced in the early 1990s by an international group of clinicians and researchers led by Gordon Guyatt. Since then it has provided a new paradigm for the scientific foundation of medicine and has influenced other disciplines outside of medicine, for example, evidence-based psychotherapy, science and government. The novel concept of evidence-based medicine is based on hierarchies of evidence from opinions of respected authorities, mechanistic reasoning, and reports of expert committees at the bottom to...

In this chapter I provide an elementary exposition of the development of Whitehead's view of objectivity and his theory of extension, with particular focus on explaining how macroscopic objects of ordinary perception and the whole structure of space-time arise out of the units of his ontology, namely, the actual occasions. I also review the scholarship on Whitehead's view of extension and discuss the major problems that arise in connection with the theory in his magnum opus, Process and Reality.

For the past forty years, Timothy Sprigge has been a major player on the British philosophical scene contributing to discussions as diverse as consciousness, the ontology of time, personal identity, animal rights, punishment, censorship and wider issues in metaphysics, ethics and the history of philosophy. He is, however, less well known for his own highly original system of metaphysics and ethics—a synthesis of absolute idealism, panpsychism and utilitarianism. This system was constructed against the current of the dominant linguistic and analytical trends in Britain. While working within an intellectual milieu largely hostile to his views, he attempted to provide color to what seemed to him a rather sterile and narrow orthodoxy. In his magnum opus, The Vindication of Absolute Idealism, he says that his manner of doing philosophy attempts to arrive at answers to the “deep ontological questions about the concrete nature of reality” instead of viewing philosophy as a self-contained intellectual game. Guy Stock says of Sprigge that he “has, in a contemporary context, a fair claim to be the most independent of thinkers within the field of metaphysics.”

Timothy Sprigge advanced an original synthesis of panpsychism and absolute idealism. He argued that consciousness is an irreducible, subjective reality that is only grasped by an introspective, phenomenological approach and constructed his ontology from what is revealed in the phenomenology. In defending the unique place of metaphysics in the pursuit of truth, he claimed that scientific investigation can never discover the essence of consciousness since it can only provide descriptions of structure and function in what we normally think of as physical existence. In this paper I present a critical evaluation of Sprigge's view focusing in particular on his conception of the nature of scientific inquiry vis-à-vis the ambitious project of his metaphysics. I argue that a naturalistic metaphysics provides a more adequate approach to the relation between science and metaphysics

Recent developments in cosmology and particle physics have led to speculation that our universe is merely one of a multitude of universes. While this notion, the multiverse hypothesis, is highly contested as legitimate science, it has nonetheless struck many physicists as a necessary consequence of the effort to construct a final, unified theory. In Process and Reality (1929), his magnum opus, Alfred North Whitehead advanced a cosmology as part of his general metaphysics of process. Part of this project involved a theory of cosmic epochs which bears a remarkable affinity to current cosmological speculation. This paper demonstrates how the basic framework of a multiverse theory is already present in Whitehead’s cosmology and defends the necessity of speculation in the quest for an explanatory description.

Sergio Sismondo argues that pharmaceutical industry-sponsored research and ghostwriting produce genuine knowledge and science (albeit commercial science) not different from established medical science. In this essay I critically evaluate Sismondo' view and conclude that the commercial medical science that has created the ghostwriting industry is a corruption of science and not merely science done in a new corporate mode. Serious harm to patients has resulted from misrepresented commercial biomedical research.

T. L. S. Sprigge produced an eclectic yet highly original system of metaphysics and ethics, a synthesis of panpsychism, absolute idealism, and utilitarianism, at a time in which orthodox analytical philosophy could only view this system as an anachronism of the nineteenth century. His critics claim that his philosophy has only historical interest to a small group of specialists in the relatively dormant tradition of British Idealism, that an attempt to defend his view of consciousness is a hopeless nonstarter, and that his Spinozistic monism can have no relevance in our intellectual culture.1 Yet others have defended Sprigge as the "most independent of thinkers within the field of metaphysics" and salute him as "a ..

Selective reporting is prevalent in the medical literature, particularly in industry-sponsored research. In this paper, we expose selective reporting that is not evident without access to internal company documents. The published report of study 329 of paroxetine in adolescents sponsored by GlaxoSmithKline claims that “paroxetine is generally well tolerated and effective for major depression in adolescents”. By contrast, documents obtained during litigation reveal that study 329 was negative for efficacy on all 8 protocol specified outcomes and positive for harm.