John O'Brien

This paper reconceptualizes “individualism” as a discursive strategy of action through which everyday Americans attempt to manage the cultural dilemma of engaging in externally imposed social obligations within a broader individualistic culture. While classic formulations have treated individualism as a strong cultural force directing actors toward voluntaristic and privatized lives, my analysis—grounded in an inductive analysis of 17 qualitative studies of religious Americans—finds individualism working primarily as a discursive strategy, through which actors frame their participation in activities influenced by external authority and communal obligation in ways that emphasize their own agency and autonomy. This revised conceptualization suggests that American individualism may not be as “deep” or powerful as is often assumed. More generally, it offers a novel approach for conceptualizing and further studying the dynamic relationship between broadly “national” and more local and communal cultures.

Disturbances of consciousness, including fluctuations in attention and awareness, are a common and clinically important symptom in dementia with Lewy bodies. In the present study we investigate potential mechanisms of such disturbances of consciousness in a clinicopathological study evaluating specific components of the cholinergic system. [3H]Epibatidine binding to the high-affinity nicotinic receptor in the temporal cortex differentiated DLB cases with and without DOC, being 62–66% higher in those with DOC. The were no differences between DLB patients with or without DOC in 125I-labeled α-bungaratoxin binding to the low-affinity nicotinic receptor, [3H]pirenzepine binding to the muscarinic M1 receptor, or in choline acetyltransferase activity. These findings provide support for the hypothesis that cholinergic activity is an important neural correlate if consciousness and suggest a mechanism of DOC in DLB involving alterations in the nicotinic receptor, composed of predominantly α4 and β2 subunits.

Review of the climate science for severe convective storms, extreme precipitation, hurricanes and typhoons, and severe snowstorms and ice storms in the US shows that the ability to detect and attribute trends varies, depending on the phenomenon. A specific subset of extreme weather and climate types affecting the country is discussed to examine these extreme weather conditions. The categories of storms described were selected as they caused property damage and loss of life. The identification of an extreme occurrence was based on meteorological properties in place of the destructiveness. The primary purpose was to examine the scientific evidence for the prevailing capability to detect trends and understand their causes for certain weather types, including severe convective storms and hurricanes and typhoons.